CTSW and NPC2

Data Source:
BioGRID (biochemical)

		CTSW	NPC2
Description		cathepsin W	NPC intracellular cholesterol transporter 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Endoplasmic Reticulum Membrane Platelet Dense Granule Lumen	Extracellular Region Extracellular Space Lysosome Endoplasmic Reticulum Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Peptidase Activity	Protein Binding Cholesterol Binding Enzyme Binding Sterol Binding Cholesterol Transfer Activity
	Biological Process	Platelet Degranulation Immune Response Proteolysis Involved In Cellular Protein Catabolic Process	Cholesterol Metabolic Process Response To Virus Phospholipid Transport Sterol Transport Regulation Of Isoprenoid Metabolic Process Cholesterol Transport Intracellular Sterol Transport Intracellular Cholesterol Transport Cholesterol Efflux Low-density Lipoprotein Particle Clearance Cholesterol Homeostasis Neutrophil Degranulation Glycolipid Transport Intermembrane Lipid Transfer
Pathways		Platelet degranulation	Neutrophil degranulation LDL clearance
Drugs
Diseases			Niemann-Pick type C disease (NPC), including: Niemann-Pick disease, type C1; Niemann-Pick disease, type C2
GWAS		Acne (severe) ( 24927181) Asthma ( 31959851) Inflammatory bowel disease ( 23128233)	Advanced glycation end-product levels ( 26915486) Blood protein levels ( 29875488) Intraocular pressure ( 31959993) Refractive error ( 32231278)
Interacting Genes		1 interacting genes: CREB3	9 interacting genes: BARD1 BRCA1 DHDDS ECT2 ERRFI1 LIG4 PAXIP1 TRIM14 USP4
Entrez ID		1521	10577
HPRD ID		03840	03008
Ensembl ID		ENSG00000172543	ENSG00000119655
Uniprot IDs		P56202	A0A024R6C0 P61916
PDB IDs			5KWY 6W5V
Enriched GO Terms of Interacting Partners?
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