CTPS1 and EPHB1

Data Source:
BioGRID (affinity chromatography technology)

		CTPS1	EPHB1
Description		CTP synthase 1	EPH receptor B1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Cytoophidium	Extracellular Region Endoplasmic Reticulum Cytosol Plasma Membrane Integral Component Of Plasma Membrane Dendrite Early Endosome Membrane Neuron Projection Receptor Complex Extracellular Exosome
	Molecular Function	CTP Synthase Activity Protein Binding ATP Binding Identical Protein Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding
	Biological Process	Nucleobase-containing Compound Metabolic Process CTP Biosynthetic Process Glutamine Metabolic Process Nucleobase-containing Small Molecule Interconversion Pyrimidine Nucleobase Biosynthetic Process T Cell Proliferation B Cell Proliferation Response To Drug 'de Novo' CTP Biosynthetic Process	Angiogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axon Guidance Skeletal Muscle Satellite Cell Activation Peptidyl-tyrosine Phosphorylation Central Nervous System Projection Neuron Axonogenesis Neurogenesis Establishment Of Cell Polarity Retinal Ganglion Cell Axon Guidance Cell-substrate Adhesion Positive Regulation Of Kinase Activity Regulation Of JNK Cascade Protein Autophosphorylation Ephrin Receptor Signaling Pathway Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of Synapse Assembly Cell Chemotaxis Dendritic Spine Development Dendritic Spine Morphogenesis Neural Precursor Cell Proliferation Regulation Of ERK1 And ERK2 Cascade Regulation Of Neuron Death Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation Negative Regulation Of Satellite Cell Differentiation
Pathways		Interconversion of nucleotide di- and triphosphates	EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells
Drugs		L-Glutamine	Fostamatinib
Diseases
GWAS		Heel bone mineral density ( 30598549)	Adult body size ( 32376654) Bitter beverage consumption ( 31046077) CV-A6-associated hand, foot, and mouth disease (severe vs mild) ( 32634583) Daytime sleep phenotypes ( 27126917) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Familial lung adenocarcinoma ( 29924316) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Iron status biomarkers (total iron binding capacity) ( 28334935) Mood instability ( 31168069) Neurofibrillary tangles ( 31497858) Small cell lung carcinoma ( 28604730) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Waist-hip ratio ( 28552196) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		4 interacting genes: CTPS2 LINC01554 YWHAG YWHAQ	13 interacting genes: ACP1 EFNA1 EFNA5 EFNB1 EFNB2 EPHB6 ERBB2 GRB10 GRB2 MTDH NCK1 PRKCG PXN
Entrez ID		1503	2047
HPRD ID		00465	02790
Ensembl ID		ENSG00000171793	ENSG00000154928
Uniprot IDs		B4E1E0 P17812	P54762
PDB IDs		2VO1 5U03	2DJS 2EAO 3ZFX 5MJA 5MJB 6UMW
Enriched GO Terms of Interacting Partners?
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