TOM1L2 and SMCR8

Data Source:
HPRD (in vitro)

		TOM1L2	SMCR8
Description		target of myb1 like 2 membrane trafficking protein	SMCR8-C9orf72 complex subunit
Image		No pdb structure
GO Annotations	Cellular Component	Endosome Membrane Extracellular Exosome	Chromatin Nucleoplasm Cytoplasm Guanyl-nucleotide Exchange Factor Complex Atg1/ULK1 Kinase Complex
	Molecular Function	Protein Binding Protein Kinase Binding Clathrin Binding	Protein Kinase Inhibitor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Kinase Binding
	Biological Process	Intracellular Protein Transport Signal Transduction Negative Regulation Of Mitotic Nuclear Division	Negative Regulation Of Protein Kinase Activity Autophagy Regulation Of Autophagy Negative Regulation Of Gene Expression Negative Regulation Of Macroautophagy Positive Regulation Of TOR Signaling Positive Regulation Of Autophagosome Maturation Negative Regulation Of Autophagosome Assembly Regulation Of TORC1 Signaling
Pathways
Drugs
Diseases
GWAS		Schizophrenia ( 28991256 25056061 29483656) TB-LM or TBLH-BMD (pleiotropy) ( 28743860) Total body bone mineral density ( 29304378)	Change in neurofilament light levels ( 31295725) Diastolic blood pressure ( 30578418) Systolic blood pressure ( 30578418)
Interacting Genes		11 interacting genes: APP FAM9B LAPTM5 MAP3K1 MYO6 NEDD4 RNF11 SMURF1 TOLLIP UBC WBP2	4 interacting genes: ATG13 C9orf72 TBK1 ULK1
Entrez ID		146691	140775
HPRD ID		18213	18075
Ensembl ID		ENSG00000175662	ENSG00000176994
Uniprot IDs		B7Z2U2 B7Z671 F5H3S6 Q6ZVM7	Q8TEV9
PDB IDs			6LT0 6V4U
Enriched GO Terms of Interacting Partners?
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