SMCR8 and TOM1L2

Data Source:
HPRD (in vitro)

		SMCR8	TOM1L2
Description		SMCR8-C9orf72 complex subunit	target of myb1 like 2 membrane trafficking protein
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleoplasm Cytoplasm Guanyl-nucleotide Exchange Factor Complex Atg1/ULK1 Kinase Complex	Endosome Membrane Extracellular Exosome
	Molecular Function	Protein Kinase Inhibitor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Kinase Binding	Protein Binding Protein Kinase Binding Clathrin Binding
	Biological Process	Negative Regulation Of Protein Kinase Activity Autophagy Regulation Of Autophagy Negative Regulation Of Gene Expression Negative Regulation Of Macroautophagy Positive Regulation Of TOR Signaling Positive Regulation Of Autophagosome Maturation Negative Regulation Of Autophagosome Assembly Regulation Of TORC1 Signaling	Intracellular Protein Transport Signal Transduction Negative Regulation Of Mitotic Nuclear Division
Pathways
Drugs
Diseases
GWAS		Change in neurofilament light levels ( 31295725) Diastolic blood pressure ( 30578418) Systolic blood pressure ( 30578418)	Schizophrenia ( 28991256 25056061 29483656) TB-LM or TBLH-BMD (pleiotropy) ( 28743860) Total body bone mineral density ( 29304378)
Interacting Genes		4 interacting genes: ATG13 C9orf72 TBK1 ULK1	11 interacting genes: APP FAM9B LAPTM5 MAP3K1 MYO6 NEDD4 RNF11 SMURF1 TOLLIP UBC WBP2
Entrez ID		140775	146691
HPRD ID		18075	18213
Ensembl ID		ENSG00000176994	ENSG00000175662
Uniprot IDs		Q8TEV9	B7Z2U2 B7Z671 F5H3S6 Q6ZVM7
PDB IDs		6LT0 6V4U
Enriched GO Terms of Interacting Partners?
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