MACROD2 and SEL1L2

Data Source:
BioGRID (two hybrid)

		MACROD2	SEL1L2
Description		mono-ADP ribosylhydrolase 2	SEL1L2 adaptor subunit of ERAD E3 ligase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus	Hrd1p Ubiquitin Ligase ERAD-L Complex Integral Component Of Membrane
	Molecular Function	Hydrolase Activity, Acting On Glycosyl Bonds Deacetylase Activity ADP-ribosylglutamate Hydrolase Activity	Ubiquitin-protein Transferase Activity
	Biological Process	Cellular Response To DNA Damage Stimulus Purine Nucleoside Metabolic Process Protein De-ADP-ribosylation Peptidyl-glutamate ADP-deribosylation	Protein Ubiquitination Ubiquitin-dependent ERAD Pathway
Pathways
Drugs
Diseases
GWAS		Advanced glycation end-product levels ( 26915486) Alzheimer's disease in APOE e4- carriers ( 25778476) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Asthma (childhood onset) ( 31379025) Asthma (time to childhood onset) x early life tobacco smoke interaction ( 31379025) Autism ( 20663923) Autism spectrum disorder ( 30804558) Body mass index ( 25673413) Body size at age 10 ( 32376654) Brain connectivity ( 23471985) Chronotype ( 30696823) Common carotid intima-media thickness in HIV infection ( 29206233) Coronary artery aneurysm in Kawasaki disease ( 27171184) Dimensional psychopathology (Negative) ( 29496196) Dimensional psychopathology (Positive) ( 29496196) Eating disorders ( 23568457) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Estimated glomerular filtration rate ( 31152163) Femoral neck bone mineral density ( 29499414) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Hip circumference ( 28552196) Intelligence (MTAG) ( 29326435) Male fertility ( 22633400) Medial orbital frontal cortex volume ( 31530798) Metabolite levels ( 23823483) Neurofibrillary tangles ( 31497858) Non-alcoholic fatty liver disease histology (other) ( 20708005) Obesity-related traits ( 23251661) Percentage gas trapping ( 26030696) Presence of antiphospholipid antibodies ( 27098658 23509613) Sleep duration ( 30846698) Smoking behaviour (age at first cigarette) ( 30679032) Thyroid-associated orbitopathy in graves' disease ( 27304844) Waist circumference adjusted for body mass index ( 28552196) Weight ( 28552196) White matter lesion progression ( 26451028)	Metabolite levels ( 23823483)
Interacting Genes
Entrez ID		140733	80343
HPRD ID		16640	19376
Ensembl ID		ENSG00000172264	ENSG00000101251
Uniprot IDs		A1Z1Q3	Q5TEA6
PDB IDs		4IQY 6Y4Y 6Y4Z 6Y73
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
Tagcloud (Intersection) ?