CRABP1 and CHRNA3

Data Source:
BioGRID (genetic interference)

		CRABP1	CHRNA3
Description		cellular retinoic acid binding protein 1	cholinergic receptor nicotinic alpha 3 subunit
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Plasma Membrane Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex Postsynaptic Density Integral Component Of Membrane Dendrite Neuron Projection Neuronal Cell Body Plasma Membrane Raft Synapse Postsynaptic Membrane
	Molecular Function	Retinoic Acid Binding Retinoid Binding Protein Binding Retinal Binding Retinol Binding	Protein Binding Ligand-gated Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Cation-selective Channel Activity Neurotransmitter Receptor Activity Acetylcholine Binding
	Biological Process	Signal Transduction Multicellular Organism Development Retinoic Acid Catabolic Process	Ion Transport Regulation Of Smooth Muscle Contraction Signal Transduction Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Nervous System Development Locomotory Behavior Regulation Of Acetylcholine Secretion, Neurotransmission Ion Transmembrane Transport Behavioral Response To Nicotine Regulation Of Membrane Potential Regulation Of Dendrite Morphogenesis Nervous System Process Excitatory Postsynaptic Potential Synaptic Transmission Involved In Micturition Acetylcholine Receptor Signaling Pathway Response To Acetylcholine
Pathways		RA biosynthesis pathway	Highly sodium permeable postsynaptic acetylcholine nicotinic receptors Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors
Drugs			Nicotine Butabarbital Methadone Fluoxetine Dextromethorphan Levamisole Ethanol Amantadine Pentolinium Bupropion Levacetylmethadol Gantacurium Epibatidine Cytisine
Diseases
GWAS		Eyebrow thickness ( 26926045)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Benign childhood epilepsy with centro-temporal spikes ( 32580138) Chronic bronchitis and chronic obstructive pulmonary disease ( 25241909) Chronic obstructive pulmonary disease ( 22080838 30804561 19300482 25101718 20173748) Chronic obstructive pulmonary disease (moderate to severe) ( 24621683) Chronic obstructive pulmonary disease (severe) ( 24621683) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cotinine levels in smokers with chronic obstructive pulmonary disease ( 29631575) Current cigarettes per day in chronic obstructive pulmonary disease ( 29767774) Dentures ( 31235808) Diffusing capacity of carbon monoxide ( 30694715) Emphysema distribution in smoking ( 27669027) Emphysema imaging phenotypes ( 26030696) Exhaled carbon monoxide levels ( 25072098) Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease ( 29631575) Familial lung cancer ( 29924316) Local histogram emphysema pattern ( 25006744) Lung adenocarcinoma ( 19836008) Lung cancer ( 18385676 18385738 19654303 18780872 30104567) Lung cancer in ever smokers ( 30104567) Lung function (FEV1/FVC) ( 31453325) Lung function (FEV1/FVC) variance ( 31453325) Nicotine dependence ( 18385739 26440539) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Obesity-related traits ( 23251661) Parental lifespan ( 30642433 29030599) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's attained age) ( 29227965) Parental longevity (mother's attained age) ( 29227965) Peripheral artery disease ( 31285632) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Pre bronchodilator FEV1 ( 26634245) Pre bronchodilator FEV1/FVC ratio ( 26634245) Pulmonary artery enlargement and chronic obstructive pulmonary disease ( 25101718) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Refractive error ( 32231278) Schizophrenia ( 28991256 25056061 29483656 30285260) Serum albumin level ( 23022100) Smoking behavior ( 20418889 20418890) Smoking behaviour (cigarettes smoked per day) ( 31089300 30617275) Smoking status (heavy vs light) ( 28520984) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		4 interacting genes: MPP3 SLC9A3R1 TH TRA2A	2 interacting genes: CHRNB4 UBQLN1
Entrez ID		1381	1136
HPRD ID		07520	07511
Ensembl ID		ENSG00000166426	ENSG00000080644
Uniprot IDs		F1T0F7 P29762	P32297
PDB IDs			4ZK4 5SYO 5TVC 6PV7 6PV8
Enriched GO Terms of Interacting Partners?
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