ADORA2A and GGT1

Data Source:
BioGRID (pull down)

		ADORA2A	GGT1
Description		adenosine A2a receptor	gamma-glutamyltransferase 1
Image
GO Annotations	Cellular Component	Golgi Membrane Intermediate Filament Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Membrane Dendrite Axolemma Neuronal Cell Body Presynaptic Active Zone Glutamatergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane	Extracellular Space Plasma Membrane Integral Component Of Membrane Extracellular Exosome
	Molecular Function	G Protein-coupled Adenosine Receptor Activity Protein Binding Enzyme Binding Type 5 Metabotropic Glutamate Receptor Binding Identical Protein Binding Protein-containing Complex Binding Alpha-actinin Binding	Peptidyltransferase Activity Leukotriene-C(4) Hydrolase Protein Binding Glutathione Hydrolase Activity Hypoglycin A Gamma-glutamyl Transpeptidase Activity Leukotriene C4 Gamma-glutamyl Transferase Activity
	Biological Process	G Protein-coupled Adenosine Receptor Signaling Pathway Regulation Of Transcription, DNA-templated Negative Regulation Of Protein Kinase Activity Phagocytosis Apoptotic Process Inflammatory Response Cellular Defense Response G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Synaptic Transmission, Cholinergic Central Nervous System Development Blood Coagulation Sensory Perception Locomotory Behavior Blood Circulation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Glutamate Secretion Positive Regulation Of Acetylcholine Secretion, Neurotransmission Regulation Of Norepinephrine Secretion Response To Caffeine Synaptic Transmission, Glutamatergic Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Negative Regulation Of Locomotion Vasodilation Response To Drug Eating Behavior Negative Regulation Of Vascular Permeability Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Cellular Protein Metabolic Process Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Astrocyte Activation Neuron Projection Morphogenesis Positive Regulation Of Protein Secretion Regulation Of Mitochondrial Membrane Potential Membrane Depolarization Regulation Of Calcium Ion Transport Positive Regulation Of Synaptic Transmission, Glutamatergic Excitatory Postsynaptic Potential Prepulse Inhibition Positive Regulation Of Long-term Synaptic Potentiation Regulation Of Synaptic Vesicle Exocytosis	Regulation Of Immune System Process Translation Proteolysis Cellular Amino Acid Metabolic Process Glutamate Metabolic Process Fatty Acid Metabolic Process Leukotriene Metabolic Process Glutathione Biosynthetic Process Glutathione Catabolic Process Xenobiotic Metabolic Process Spermatogenesis Protein Phosphopantetheinylation Cysteine Biosynthetic Process Peptide Modification Zymogen Activation Response To Estradiol Response To Lipopolysaccharide Response To Tumor Necrosis Factor Regulation Of Inflammatory Response Leukotriene D4 Biosynthetic Process
Pathways		NGF-independant TRKA activation Adenosine P1 receptors G alpha (s) signalling events Surfactant metabolism ADORA2B mediated anti-inflammatory cytokines production	Glutathione synthesis and recycling Synthesis of Leukotrienes (LT) and Eoxins (EX) Aflatoxin activation and detoxification Defective GGT1 causes Glutathionuria (GLUTH) Defective GGT1 causes Glutathionuria (GLUTH) LTC4-CYSLTR mediated IL4 production
Drugs		Caffeine Theophylline Mefloquine Lamotrigine Adenosine Dyphylline Pentoxifylline Enprofylline Oxtriphylline Theobromine Binodenoson Defibrotide Apadenoson Atl146e Regadenoson 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol Doxofylline Istradefylline 8-chlorotheophylline	Glutathione
Diseases
GWAS		Acne (severe) ( 24927181) Coffee consumption (cups per day) ( 31217584) Coronary artery disease ( 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Severity of nausea and vomiting of pregnancy ( 29563502)	Acne (severe) ( 24927181) Blood metabolite levels ( 24816252) Blood protein levels ( 23696881) Gamma glutamyl transferase levels ( 29403010 32084209) Gamma glutamyl transpeptidase ( 21909109) Hematological and biochemical traits ( 20139978) Liver enzyme levels ( 18940312) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Protein quantitative trait loci ( 18464913) Serum metabolite levels ( 23093944) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995)
Interacting Genes		22 interacting genes: ACTN1 ACTN2 ACTN3 ACTN4 ADA BET1 CHN1 CYTH2 DRD2 GPR37 HNRNPH3 HRH3 NAMPT NECAB2 PDHB POMZP3 PPM1J RHBDD2 SLC25A39 SLC4A1AP SPNS1 SYNGR1	3 interacting genes: CD53 KCNMA1 NAMPT
Entrez ID		135	2678
HPRD ID		00043	01980
Ensembl ID		ENSG00000128271	ENSG00000100031
Uniprot IDs		A8K1F6 B3KVQ4 P29274 X5DNB4	A0A140VJJ9 P19440
PDB IDs		1MMH 1UPE 2YDO 2YDV 3EML 3PWH 3QAK 3REY 3RFM 3UZA 3UZC 3VG9 3VGA 4EIY 4UG2 4UHR 5G53 5IU4 5IU7 5IU8 5IUA 5IUB 5JTB 5K2A 5K2B 5K2C 5K2D 5MZJ 5MZP 5N2R 5NLX 5NM2 5NM4 5OLG 5OLH 5OLO 5OLV 5OLZ 5OM1 5OM4 5UIG 5UVI 5VRA 5WF5 5WF6 6AQF 6GDG 6GT3 6JZH 6MH8 6PS7 6S0L 6S0Q 6ZDR 6ZDV	4GDX 4GG2 4Z9O 4ZBK 4ZC6 4ZCG 5V4Q
Enriched GO Terms of Interacting Partners?
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