TYW5 and MARS2

Data Source:
BioGRID (biochemical)

		TYW5	MARS2
Description		tRNA-yW synthesizing protein 5	methionyl-tRNA synthetase 2, mitochondrial
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Mitochondrial Matrix
	Molecular Function	TRNA Binding Iron Ion Binding 2-oxoglutarate-dependent Dioxygenase Activity Protein Homodimerization Activity TRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase Activity	Methionine-tRNA Ligase Activity ATP Binding
	Biological Process	TRNA Modification Wybutosine Biosynthetic Process	TRNA Aminoacylation For Protein Translation Methionyl-tRNA Aminoacylation
Pathways		Synthesis of wybutosine at G37 of tRNA(Phe)	Mitochondrial tRNA aminoacylation
Drugs
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) QT interval (sulfonylurea treatment interaction) ( 27958378) Schizophrenia ( 28991256 29483656 23974872) Sleep duration ( 30846698) Type 2 diabetes ( 25760438)	Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Idiopathic dilated cardiomyopathy ( 29495422) Morning person ( 30696823) Schizophrenia ( 25056061 29483656) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes			1 interacting genes: APP
Entrez ID		129450	92935
HPRD ID		08232	14363
Ensembl ID		ENSG00000162971	ENSG00000247626
Uniprot IDs		A2RUC4	Q96GW9
PDB IDs		3AL5 3AL6
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?