ANTXR2 and FRAS1

Data Source:
BioGRID (affinity chromatography technology)

		ANTXR2	FRAS1
Description		ANTXR cell adhesion molecule 2	Fraser extracellular matrix complex subunit 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Membrane Plasma Membrane Cell Surface Endosome Membrane Integral Component Of Membrane	Basement Membrane Plasma Membrane Integral Component Of Membrane Collagen-containing Extracellular Matrix
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Metal Ion Binding	Extracellular Matrix Structural Constituent Metal Ion Binding
	Biological Process	Toxin Transport	Morphogenesis Of An Epithelium Metanephros Morphogenesis Cell Communication Protein Transport Embryonic Limb Morphogenesis Skin Development Roof Of Mouth Development
Pathways
Drugs		MDX-1303
Diseases		Infantile systemic hyalinosis and juvenile hyaline fibromatosis	Fraser syndrome
GWAS		Adult body size ( 32376654) Ankylosing spondylitis ( 21743469 20062062) Bipolar disorder (inflammation and infection response interaction) ( 25781172) Carotid plaque burden ( 28282560) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Essential hypertension (time to event) ( 32589924) Hand grip strength ( 29691431) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Monocyte count ( 32888494) Myopia ( 27182965) Neutrophil percentage of white cells ( 32888494 27863252) Refractive error ( 32231278) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Spherical equivalent or myopia (age of diagnosis) ( 29808027) White blood cell count ( 32888494)	Blond vs. brown/black hair color ( 30531825) Hair morphology ( 19896111) Hair shape ( 29220522) Hemoglobin ( 32888494) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Left ventricular obstructive tract defect (maternal effect) ( 28468790) Lung function (FEV1/FVC) ( 30804560) Night sleep phenotypes ( 27126917) QT interval ( 29213071) Response to carboplatin in ovarian cancer (MTT IC50) ( 27047539) Retinal detachment or retinal break ( 31816047) Uric acid levels ( 23703922)
Interacting Genes		8 interacting genes: COL4A2 COL4A3 COL4A4 COL4A5 LAMB1 LAMC1 LRP6 SMAD2
Entrez ID		118429	80144
HPRD ID		07452	06382
Ensembl ID		ENSG00000163297	ENSG00000138759
Uniprot IDs		A4FUA5 J3KPY9 P58335 Q32Q26	Q86XX4
PDB IDs		1SHT 1SHU 1T6B 1TZN
Enriched GO Terms of Interacting Partners?
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