CKB and JAG2

Data Source:
BioGRID (affinity chromatography technology)

		CKB	JAG2
Description		creatine kinase B	jagged canonical Notch ligand 2
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytosol Dendrite Neuronal Cell Body Extracellular Exosome	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Creatine Kinase Activity Protein Binding ATP Binding Kinase Activity Ubiquitin Protein Ligase Binding	Notch Binding Calcium Ion Binding Protein Binding Growth Factor Activity
	Biological Process	Creatine Metabolic Process Phosphorylation Cerebellum Development Substantia Nigra Development Cellular Chloride Ion Homeostasis Phosphocreatine Biosynthetic Process	Skeletal System Development In Utero Embryonic Development Respiratory System Process Notch Signaling Pathway Spermatogenesis Auditory Receptor Cell Fate Commitment Morphogenesis Of Embryonic Epithelium Cell Differentiation Regulation Of Cell Adhesion T Cell Differentiation Regulation Of Cell Population Proliferation Odontogenesis Of Dentin-containing Tooth Gamma-delta T Cell Differentiation Thymic T Cell Selection Positive Regulation Of Notch Signaling Pathway Epithelial Cell Apoptotic Process Involved In Palatal Shelf Morphogenesis
Pathways		Creatine metabolism	Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus
Drugs		Creatine Phosphocreatine
Diseases
GWAS		Adult body size ( 32376654) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778) Extremely high intelligence ( 29520040) Height ( 28552196 31562340) Schizophrenia ( 25056061)	Brain morphology (MOSTest) ( 32665545) Fasting plasma glucose ( 31932636) Red blood cell count ( 32888494)
Interacting Genes		15 interacting genes: ACD ARIH2 ASB9 CKM ERBB2 GOLGA2 ILK MLH1 POT1 PPP1CA SERP2 TAB1 TERF1 TINF2 TRIM63	8 interacting genes: ATN1 ATXN7 CACNA1A GFI1B MIB2 NOTCH1 NOTCH2 NOTCH3
Entrez ID		1152	3714
HPRD ID		00423	03981
Ensembl ID		ENSG00000166165	ENSG00000184916
Uniprot IDs		G3V4N7 P12277 V9HWH2	Q9Y219
PDB IDs		3B6R 3DRB 3DRE 6V9H	5MW5 5MW7 5MWF
Enriched GO Terms of Interacting Partners?
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