TRIM9 and DNAAF2

Data Source:
BioGRID (affinity chromatography technology)

		TRIM9	DNAAF2
Description		tripartite motif containing 9	dynein axonemal assembly factor 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Synaptic Vesicle Dendrite Presynaptic Cytosol	Extracellular Region Cytoplasm Cytosol
	Molecular Function	SNARE Binding Protein Binding Zinc Ion Binding Protein Domain Specific Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Synaptic Vesicle Exocytosis Protein Ubiquitination Negative Regulation Of SNARE Complex Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Calcium Ion-dependent Exocytosis	Cilium Or Flagellum-dependent Cell Motility In Utero Embryonic Development Epithelial Cilium Movement Involved In Extracellular Fluid Movement Response To Retinoic Acid Outer Dynein Arm Assembly Inner Dynein Arm Assembly Cilium-dependent Cell Motility Establishment Of Left/right Asymmetry Axonemal Dynein Complex Assembly
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases			Primary ciliary dyskinesia, including: Primary ciliary dyskinesia; Kartagener syndrome
GWAS		Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Psychosis (atypical) ( 24132900) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576) Urate levels (BMI interaction) ( 25811787)	Carotid intima media thickness ( 26343869)
Interacting Genes		32 interacting genes: AP3M1 BTRC CHFR CSNK1D CWF19L2 DTNBP1 DTX3L EVL EXOC1 FAM124B FAM90A1 GFM2 LONRF1 MDM2 MNAT1 MUL1 NCF1 NFKBID NTAQ1 PCGF3 RNF166 RPL4P5 SNAP25 SPG21 TRIM27 TRIM46 TRIM8 TSSK3 USP2 USP21 UTP25 VASP	1 interacting genes: APP
Entrez ID		114088	55172
HPRD ID		05947	12627
Ensembl ID		ENSG00000100505	ENSG00000165506
Uniprot IDs		Q9C026	Q9NVR5
PDB IDs		2DB8
Enriched GO Terms of Interacting Partners?
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