CHRNA5 and ALDH6A1

Data Source:
BioGRID (genetic interference)

		CHRNA5	ALDH6A1
Description		cholinergic receptor nicotinic alpha 5 subunit	aldehyde dehydrogenase 6 family member A1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex Neuron Projection Synapse Postsynaptic Membrane Dopaminergic Synapse	Nucleoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	Protein Binding Ligand-gated Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Cation-selective Channel Activity Neurotransmitter Receptor Activity	Fatty-acyl-CoA Binding RNA Binding Methylmalonate-semialdehyde Dehydrogenase (acylating) Activity Malonate-semialdehyde Dehydrogenase (acetylating) Activity
	Biological Process	Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Ion Transmembrane Transport Response To Nicotine Behavioral Response To Nicotine Regulation Of Membrane Potential Nervous System Process Excitatory Postsynaptic Potential Regulation Of Synaptic Vesicle Exocytosis	Thymine Catabolic Process Valine Metabolic Process Valine Catabolic Process Branched-chain Amino Acid Catabolic Process Thymine Metabolic Process Brown Fat Cell Differentiation
Pathways		Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors	Branched-chain amino acid catabolism
Drugs		Nicotine Butabarbital Ethanol	NADH
Diseases
GWAS		Airflow obstruction ( 22837378) Autism spectrum disorder or schizophrenia ( 28540026) Chronic obstructive pulmonary disease ( 22080838 28166215 19300482 20173748) Cotinine levels in smokers with chronic obstructive pulmonary disease ( 29631575) Diffusing capacity of carbon monoxide ( 30694715) Emphysema distribution in smoking ( 27669027) Emphysema imaging phenotypes ( 26030696) Exhaled carbon monoxide levels ( 25072098) Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease ( 29631575) FagerstrÓ§m test for nicotine dependence ( 31294817) Local histogram emphysema pattern ( 25006744) Lung adenocarcinoma ( 28604730 19836008) Lung cancer ( 18385676 28604730 18385738 18780872 27393504) Lung cancer in ever smokers ( 28604730) Nicotine dependence ( 18385739 26440539) Non-small cell lung cancer ( 31326317) Parental lifespan ( 30642433 29030599) Parental longevity (both parents in top 10%) ( 29227965) Parental longevity (combined parental age at death) ( 29227965) Parental longevity (father's age at death) ( 29227965) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Pre bronchodilator FEV1 ( 26634245) Pre bronchodilator FEV1/FVC ratio ( 26634245) Pulmonary artery enlargement and chronic obstructive pulmonary disease ( 25101718) Pulmonary function ( 21946350) Schizophrenia ( 25056061 29483656) Serum albumin level ( 23022100) Small cell lung carcinoma ( 28604730) Smoking behavior ( 22832964 20418889) Smoking behaviour (cigarettes smoked per day) ( 30679032) Smoking status (heavy vs light) ( 28520984) Time to smoke first cigarette in the morning ( 31294817) Urate levels ( 31578528) Youthful appearance (self-reported) ( 32339537)	Blood protein levels ( 28240269) Red blood cell count ( 32888494) Red cell distribution width ( 27863252) Refractive error ( 32231278)
Interacting Genes		1 interacting genes: CHRNB4	1 interacting genes: LMO2
Entrez ID		1138	4329
HPRD ID		00334	04416
Ensembl ID		ENSG00000169684	ENSG00000119711
Uniprot IDs		H0YM98 P30532 Q6EWN4	A0A024R6G4 Q02252
PDB IDs
Enriched GO Terms of Interacting Partners?
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