TWF2 and MANF

Data Source:
BioGRID (affinity chromatography technology)

		TWF2	MANF
Description		twinfilin actin binding protein 2	mesencephalic astrocyte derived neurotrophic factor
Image
GO Annotations	Cellular Component	Cytoplasm Actin Filament Myofibril Lamellipodium Filopodium Growth Cone Stereocilium Perinuclear Region Of Cytoplasm Extracellular Exosome	Extracellular Region Extracellular Space Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Cytosol Sarcoplasmic Reticulum Lumen Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Binding Actin Monomer Binding Protein Kinase C Binding Protein Binding ATP Binding Phosphatidylinositol-4,5-bisphosphate Binding Cadherin Binding Actin Filament Binding	RNA Binding Protein Binding Growth Factor Activity Sulfatide Binding
	Biological Process	Regulation Of Lamellipodium Assembly Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Neuron Projection Development Cell Projection Organization Actin Filament Depolymerization Negative Regulation Of Actin Filament Polymerization Regulation Of Microvillus Length Regulation Of Actin Cytoskeleton Organization Sequestering Of Actin Monomers Positive Regulation Of Axon Extension Barbed-end Actin Filament Capping Cellular Response To Retinoic Acid Cellular Response To Growth Factor Stimulus	Platelet Degranulation Response To Unfolded Protein Signal Transduction Neuron Projection Development Dopaminergic Neuron Differentiation Regulation Of Response To Endoplasmic Reticulum Stress
Pathways			Platelet degranulation
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Schizophrenia ( 23974872)	Depressive symptom (appetite changes) (binary trait) ( 31530331) Depressive symptoms (binary sum-score) ( 31530331) Depressive symptoms (sum-score) ( 31530331) Diverticular disease ( 30177863)
Interacting Genes		6 interacting genes: ARHGDIA CHGB FOXJ1 ILK POT1 TERF2IP	1 interacting genes: ZDHHC17
Entrez ID		11344	7873
HPRD ID		08464	03558
Ensembl ID		ENSG00000247596	ENSG00000145050
Uniprot IDs		Q6IBS0	A8K878 P55145
PDB IDs		2VAC 2W0I	2KVD 2KVE 2W51
Enriched GO Terms of Interacting Partners?
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