COPE and GDF15

Data Source:
BioGRID (affinity chromatography technology)

		COPE	GDF15
Description		COPI coat complex subunit epsilon	growth differentiation factor 15
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GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol COPI Vesicle Coat Transport Vesicle	Extracellular Region Extracellular Space Nucleus Cytoplasm Golgi Apparatus Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Structural Molecule Activity Protein Binding	Cytokine Activity Protein Binding Growth Factor Activity Protein Homodimerization Activity BMP Receptor Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Intra-Golgi Vesicle-mediated Transport Protein Transport	Activation Of MAPK Activity Reduction Of Food Intake In Response To Dietary Excess Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation BMP Signaling Pathway Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Negative Regulation Of Multicellular Organism Growth Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase B Signaling SMAD Protein Signal Transduction Negative Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Myoblast Fusion
Pathways		COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
Drugs
Diseases
GWAS			Blood protein levels ( 30072576 29875488) Blood protein levels in cardiovascular risk ( 28369058) Coffee consumption ( 31046077) Growth differentiation factor-15 levels ( 29628937) Hyperemesis gravidarum ( 29563502) Severity of nausea and vomiting of pregnancy ( 29563502)
Interacting Genes		14 interacting genes: ARF1 CDC42 CDC42EP3 COPA COPB1 COPB2 COPG1 COPG2 EFHC2 ERCC6 RCHY1 SCYL1 TMED10 WBP2	7 interacting genes: CBX3 HOXA1 KRTAP12-2 MAPK14 MDFI NLGN3 TACC3
Entrez ID		11316	9518
HPRD ID		06089	05608
Ensembl ID		ENSG00000105669	ENSG00000130513
Uniprot IDs		M0QXB4 O14579	Q99988
PDB IDs		6TZT 6U3V	5VT2 5VZ3 5VZ4 6Q2J
Enriched GO Terms of Interacting Partners?
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