B4GALT7 and PBRM1

Data Source:
BioGRID (affinity chromatography technology)

		B4GALT7	PBRM1
Description		beta-1,4-galactosyltransferase 7	polybromo 1
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GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Integral Component Of Membrane Golgi Cisterna Membrane	Nuclear Chromosome Nucleoplasm RSC-type Complex
	Molecular Function	Beta-N-acetylglucosaminylglycopeptide Beta-1,4-galactosyltransferase Activity Protein Binding Galactosyltransferase Activity Manganese Ion Binding Xylosylprotein 4-beta-galactosyltransferase Activity	DNA Binding Chromatin Binding Protein Binding
	Biological Process	Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Proteoglycan Metabolic Process Cellular Protein Modification Process Protein N-linked Glycosylation Protein Phosphopantetheinylation Proteoglycan Biosynthetic Process Glycosaminoglycan Metabolic Process Negative Regulation Of Fibroblast Proliferation Glycosylation Supramolecular Fiber Organization	Mitotic Cell Cycle Chromatin Remodeling Negative Regulation Of Cell Population Proliferation ATP-dependent Chromatin Remodeling
Pathways		A tetrasaccharide linker sequence is required for GAG synthesis Defective B4GALT7 causes EDS, progeroid type	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Drugs
Diseases		Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS) Ehlers-Danlos syndrome, progeroid form
GWAS		Blood protein levels ( 30072576) Methadone dose in opioid dependence ( 28115739) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972 31043756) Bipolar disorder with mood-incongruent psychosis ( 23092984) Blood protein levels ( 29875488) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) General cognitive ability ( 29844566) Hemoglobin levels ( 32327693) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Intelligence (MTAG) ( 29326435) Lymphocyte counts ( 32888494) Major mood disorders ( 20081856) Monocyte count ( 32888494) Red cell distribution width ( 32888494) Schizophrenia ( 28991256 25056061 29483656 30285260 23974872) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
Interacting Genes		6 interacting genes: CYSRT1 KRT31 KRTAP10-3 KRTAP10-7 RABGGTB TMEM14B	11 interacting genes: APP H2AC20 H2BC21 H3C1 H4C1 PTEN PTS SMARCA4 SUMO2 ZDHHC17 ZNF512B
Entrez ID		11285	55193
HPRD ID		05060	07302
Ensembl ID		ENSG00000027847	ENSG00000163939
Uniprot IDs		B3KMT1 Q9UBV7	Q86U86
PDB IDs		4IRP 4IRQ	2KTB 3G0J 3HMF 3IU5 3IU6 3K2J 3LJW 3MB4 3TLP 4Q0N 4Q0O 4Y03 5E7D 5FH6 5FH7 5FH8 5HRV 5HRW 5HRX 5II1 5II2 5IID 6OXB 6ZN6 6ZNV 6ZS3 6ZS4
Enriched GO Terms of Interacting Partners?
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