PRRT2 and KAT8

Data Source:
BioGRID (affinity chromatography technology)

		PRRT2	KAT8
Description		proline rich transmembrane protein 2	lysine acetyltransferase 8
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Synaptic Vesicle Membrane Integral Component Of Membrane Synaptic Vesicle Membrane Vesicle Presynaptic Membrane Dendritic Spine Axon Terminus Presynapse Postsynaptic Density Membrane	Histone Acetyltransferase Complex Kinetochore Nucleus Nucleoplasm Nuclear Matrix MLL1 Complex MSL Complex
	Molecular Function	Protein Binding Syntaxin-1 Binding	Transcription Coregulator Activity Histone Acetyltransferase Activity Protein Binding Transcription Factor Binding Acetyltransferase Activity Enzyme Binding Methylated Histone Binding Histone Binding Histone Acetyltransferase Activity (H4-K5 Specific) Histone Acetyltransferase Activity (H4-K8 Specific) Metal Ion Binding Histone Acetyltransferase Activity (H4-K16 Specific)
	Biological Process	Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Negative Regulation Of SNARE Complex Assembly Neuromuscular Process Controlling Posture Negative Regulation Of Short-term Synaptic Potentiation	Regulation Of Autophagy Histone Acetylation Myeloid Cell Differentiation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II
Pathways			HATs acetylate histones
Drugs
Diseases
GWAS			Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body mass index ( 25673413) Family history of Alzheimer's disease ( 30617256) Parkinson's disease ( 28892059) Triglyceride levels ( 32154731)
Interacting Genes		8 interacting genes: AQP6 F2RL1 GPRC5D MFSD14B SLC10A6 SMIM5 SNAP25 TLCD4	12 interacting genes: ATM BAZ2A FOXP3 H4C1 KANSL1 KMT2A MSL3 PAF1 PLAU RNF2 TP53 TP53BP1
Entrez ID		112476	84148
HPRD ID		13995	11381
Ensembl ID		ENSG00000167371	ENSG00000103510
Uniprot IDs		Q7Z6L0	Q9H7Z6
PDB IDs			2GIV 2PQ8 2Y0M 3QAH 3TOA 3TOB 4DNC 5H43 5J8C 5J8F 5WCI 6BA2 6BA4 6CT2 6OIN 6OIO 6OIP 6OIQ 6OIR 6OWH 6OWI 6PD8 6PD9 6PDA 6PDB 6PDC 6PDD 6PDE 6PDF 6PDG 7CMR
Enriched GO Terms of Interacting Partners?
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