MRPL3 and CD80

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		MRPL3	CD80
Description		mitochondrial ribosomal protein L3	CD80 molecule
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Large Ribosomal Subunit	Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Protein Complex Involved In Cell Adhesion
	Molecular Function	RNA Binding Structural Constituent Of Ribosome	Virus Receptor Activity Protein Binding Coreceptor Activity
	Biological Process	Translation Mitochondrial Translational Elongation Mitochondrial Translational Termination	Immune Response Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Cytokine-mediated Signaling Pathway T Cell Costimulation Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interleukin-2 Production Intracellular Signal Transduction Positive Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Kinase B Signaling Cellular Response To Lipopolysaccharide
Pathways		Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination	PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer CD28 co-stimulation CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway CTLA4 inhibitory signaling Interleukin-10 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs			Abatacept Galiximab Belatacept
Diseases
GWAS		Body mass index ( 26426971)	Asthma ( 32296059) Autoimmune thyroid disease ( 32581359) Carotid plaque burden ( 28282560) Celiac disease ( 20190752) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Lobular breast cancer (menopausal hormone therapy interaction) ( 24080446) Primary biliary cholangitis ( 28425483 23000144 21399635 26394269 28062665) Primary biliary cirrhosis ( 22961000) Systemic lupus erythematosus ( 23273568 25862617) Systemic sclerosis ( 31672989) Vitiligo ( 27723757 22561518)
Interacting Genes		2 interacting genes: APP ERCC6	5 interacting genes: CD274 CD28 CD86 CTLA4 NGFR
Entrez ID		11222	941
HPRD ID		06175	00202
Ensembl ID		ENSG00000114686	ENSG00000121594
Uniprot IDs		P09001	A0N0P2 P33681
PDB IDs		3J7Y 3J9M 5OOL 5OOM 6I9R 6NU2 6NU3 6VLZ 6VMI 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG	1DR9 1I8L
Enriched GO Terms of Interacting Partners?
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