CEP250 and FRMD5

Data Source:
BioGRID (pull down)

		CEP250	FRMD5
Description		centrosomal protein 250	FERM domain containing 5
Image			No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Centrosome Centriole Microtubule Organizing Center Cytosol Protein-containing Complex Ciliary Basal Body Perinuclear Region Of Cytoplasm Extracellular Exosome	Cytoskeleton Adherens Junction Integral Component Of Membrane
	Molecular Function	Protein Binding Protein C-terminus Binding Protein Kinase Binding Protein Domain Specific Binding	Integrin Binding Protein Binding Cytoskeletal Protein Binding Protein Kinase Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Localization Regulation Of G2/M Transition Of Mitotic Cell Cycle Centriole-centriole Cohesion Regulation Of Centriole-centriole Cohesion Protein Localization To Organelle Detection Of Light Stimulus Involved In Visual Perception Cilium Assembly Ciliary Basal Body-plasma Membrane Docking Positive Regulation Of Protein Localization To Centrosome Non-motile Cilium Assembly	Regulation Of Cell Migration Actomyosin Structure Organization Positive Regulation Of Cell Adhesion Negative Regulation Of Cell Motility
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Brain morphology (MOSTest) ( 32665545) Height ( 25429064 18391951) Refractive error ( 32231278) Ulcerative colitis ( 23128233) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Hemoglobin levels ( 32327693) Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643) Serum albumin level ( 23022100) Triglyceride levels ( 28334899) Triglycerides ( 24097068 25961943 20686565) Urinary tract infection frequency ( 28928442) Uterine fibroid number (single vs multiple) ( 30196971)
Interacting Genes		6 interacting genes: APP ATF7IP KAT2B NEK2 PLEKHA5 YWHAG	1 interacting genes: NELFCD
Entrez ID		11190	84978
HPRD ID		09877	17493
Ensembl ID		ENSG00000126001	ENSG00000171877
Uniprot IDs		Q9BV73	A0A087WVP2 B3KVN9 B5MC67 H0YKW6 Q7Z6J6
PDB IDs		6OQA
Enriched GO Terms of Interacting Partners?
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