NISCH and TWF2

Data Source:
BioGRID (two hybrid)

		NISCH	TWF2
Description		nischarin	twinfilin actin binding protein 2
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Early Endosome Cytosol Plasma Membrane Microtubule Cytoskeleton Membrane Intracellular Membrane-bounded Organelle Intercellular Bridge Recycling Endosome	Cytoplasm Actin Filament Myofibril Lamellipodium Filopodium Growth Cone Stereocilium Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Integrin Binding Protein Binding Protein Kinase Binding Phosphatidylinositol Binding Identical Protein Binding	RNA Binding Actin Monomer Binding Protein Kinase C Binding Protein Binding ATP Binding Phosphatidylinositol-4,5-bisphosphate Binding Cadherin Binding Actin Filament Binding
	Biological Process	Glucose Metabolic Process Apoptotic Process Regulation Of Blood Pressure Rac Protein Signal Transduction Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Regulation Of Synaptic Transmission, GABAergic Norepinephrine Secretion	Regulation Of Lamellipodium Assembly Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Neuron Projection Development Cell Projection Organization Actin Filament Depolymerization Negative Regulation Of Actin Filament Polymerization Regulation Of Microvillus Length Regulation Of Actin Cytoskeleton Organization Sequestering Of Actin Monomers Positive Regulation Of Axon Extension Barbed-end Actin Filament Capping Cellular Response To Retinoic Acid Cellular Response To Growth Factor Stimulus
Pathways
Drugs		Tizanidine Agmatine Moxonidine
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972 31043756) General cognitive ability ( 29844566) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Parkinson's disease ( 28892059) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Schizophrenia ( 25056061 29483656 23974872) Triglyceride levels ( 32203549) Waist-hip ratio ( 20935629)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Schizophrenia ( 23974872)
Interacting Genes		4 interacting genes: AR IRS4 ITGA5 PTGER4	6 interacting genes: ARHGDIA CHGB FOXJ1 ILK POT1 TERF2IP
Entrez ID		11188	11344
HPRD ID		11391	08464
Ensembl ID		ENSG00000010322	ENSG00000247596
Uniprot IDs		Q9Y2I1	Q6IBS0
PDB IDs		3P0C	2VAC 2W0I
Enriched GO Terms of Interacting Partners?
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