B4GAT1 and SCN2A

Data Source:
HPRD (in vivo)

		B4GAT1	SCN2A
Description		beta-1,4-glucuronyltransferase 1	sodium voltage-gated channel alpha subunit 2
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Integral Component Of Golgi Membrane Extracellular Exosome	Voltage-gated Sodium Channel Complex Plasma Membrane Integral Component Of Plasma Membrane Intercalated Disc Membrane T-tubule Axon Intrinsic Component Of Plasma Membrane Node Of Ranvier Paranode Region Of Axon Sodium Channel Complex Glutamatergic Synapse Integral Component Of Presynaptic Membrane
	Molecular Function	Protein Binding N-acetyllactosaminide Beta-1,3-N-acetylglucosaminyltransferase Activity Glucuronosyltransferase Activity Metal Ion Binding	Voltage-gated Ion Channel Activity Voltage-gated Sodium Channel Activity
	Biological Process	Protein O-linked Glycosylation Keratan Sulfate Biosynthetic Process Poly-N-acetyllactosamine Biosynthetic Process Protein O-linked Mannosylation	Sodium Ion Transport Nervous System Development Memory Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Neuronal Action Potential Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Myelination Neuron Apoptotic Process Cellular Response To Hypoxia Membrane Depolarization During Action Potential
Pathways		Keratan sulfate biosynthesis Defective LARGE causes MDDGA6 and MDDGB6 O-linked glycosylation	Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation
Drugs			Tramadol Ranolazine Phenytoin Topiramate Valproic acid Lamotrigine Carbamazepine Oxcarbazepine Propofol Cocaine Zonisamide Promethazine Tetrodotoxin Brivaracetam Tetracaine Amylocaine Propoxycaine Pramocaine Pentoxyverine Dichlorobenzyl alcohol Metergoline Bioallethrin Amylmetacresol Fish oil
Diseases			Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS			Adult body size ( 32376654) Bipolar disorder ( 31043756) Diastolic blood pressure ( 30224653) Epilepsy ( 30531953) Factor VII activity ( 30642921) Febrile seizures ( 25344690) Febrile seizures (MMR vaccine-related) ( 25344690) Febrile seizures (MMR vaccine-unrelated) ( 25344690) Focal epilepsy ( 30531953) Generalized epilepsy ( 30531953) Periodontitis (DPAL) ( 24024966) Refractive error ( 32231278) Trunk fat mass ( 28552196) Urinary sodium excretion ( 31409800)
Interacting Genes		1 interacting genes: PPP1CC	5 interacting genes: ANK3 ARHGEF10L MPP3 RNF130 SCN4B
Entrez ID		11041	6326
HPRD ID		09270	03133
Ensembl ID		ENSG00000174684	ENSG00000136531
Uniprot IDs		A0A024R5F9 O43505	Q99250
PDB IDs			2KAV 4JPZ 4RLY 6BUT 6J8E
Enriched GO Terms of Interacting Partners?
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