IQGAP2 and ALG8

Data Source:
HPRD (in vivo)

		IQGAP2	ALG8
Description		IQ motif containing GTPase activating protein 2	ALG8 alpha-1,3-glucosyltransferase
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Microvillus Cell Surface Actin Cytoskeleton Lamellipodium Filopodium Secretory Granule Membrane Extracellular Exosome	Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Actin Binding GTPase Inhibitor Activity GTPase Activator Activity Calmodulin Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Small GTPase Binding Actin Filament Binding Arp2/3 Complex Binding	Alpha-1,3-mannosyltransferase Activity Dolichyl-phosphate-glucose-glycolipid Alpha-glucosyltransferase Activity Protein Binding Dolichyl Pyrophosphate Glc1Man9GlcNAc2 Alpha-1,3-glucosyltransferase Activity
	Biological Process	Signal Transduction Regulation Of Actin Cytoskeleton Organization Negative Regulation Of GTPase Activity Arp2/3 Complex-mediated Actin Nucleation Neutrophil Degranulation Positive Regulation Of GTPase Activity Thrombin-activated Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Reorganization	Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process Oligosaccharide-lipid Intermediate Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Mannosylation
Pathways		RHO GTPases activate IQGAPs Neutrophil degranulation	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG8 causes ALG8-CDG (CDG-1h)
Drugs
Diseases			Congenital disorders of glycosylation (CDG) type I
GWAS		Dental caries (decayed, missing and filled teeth) ( 31533690) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Gut microbiota relative abundance (Sutterella) ( 33208821) HDL cholesterol levels ( 32203549) Hearing impairment ( 20068591) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494) Late-onset Alzheimer's disease ( 27770636) Mean corpuscular hemoglobin ( 32888494) Mean platelet volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Phenylephrine infusion rate during anesthesia ( 31455332) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494) Red blood cell count ( 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971)	Depression in smokers ( 30219690) Tourette syndrome ( 30818990)
Interacting Genes		5 interacting genes: ACTR2 CALM1 CDC42 RAC1 RHOG	12 interacting genes: BIK CLRN1 CREB3 CREB3L1 CYB5R3 FAM209A GPX8 LMNA MFSD6 NAE1 RPS6KA5 SAR1A
Entrez ID		10788	79053
HPRD ID		09253	10480
Ensembl ID		ENSG00000145703	ENSG00000159063
Uniprot IDs		B7Z7U6 B7Z7X2 Q13576 Q59HA3	A0A024R5K5 Q9BVK2
PDB IDs		3IEZ 4EZA 5CJP
Enriched GO Terms of Interacting Partners?
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