CD226 and GALR1

Data Source:
BioGRID (affinity chromatography technology)

		CD226	GALR1
Description		CD226 molecule	galanin receptor 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Raft	Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Integrin Binding Protein Binding Protein Kinase Binding Cell Adhesion Molecule Binding	Galanin Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding Neuropeptide Binding
	Biological Process	Cytokine Production Positive Regulation Of Natural Killer Cell Cytokine Production Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Immunoglobulin Mediated Immune Response Cell Adhesion Signal Transduction Cell Recognition Positive Regulation Of Interferon-gamma Production Positive Regulation Of Mast Cell Activation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cortisol Secretion
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Peptide ligand-binding receptors G alpha (i) signalling events
Drugs
Diseases		Type I diabetes mellitus
GWAS		Autoimmune thyroid disease ( 32581359) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Eosinophil counts ( 32888494) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494 27863252) Inflammatory bowel disease ( 23128233) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean platelet volume ( 22139419 19820697 31194788 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244) Neutrophil count ( 32888494) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Primary sclerosing cholangitis ( 23603763 27992413) Reticulocyte fraction of red cells ( 32888494) Rheumatoid arthritis ( 30423114 24390342) Type 1 diabetes ( 21829393 25751624 17554260) White blood cell count ( 32888494)	Blood osmolality (transformed sodium) ( 28360221) Height ( 31562340) Metabolite levels ( 31628463) Obesity-related traits ( 23251661) Smoking initiation (ever regular vs never regular) ( 31089300)
Interacting Genes		4 interacting genes: FYN ITGB2 NECTIN2 PVR	2 interacting genes: GAL SNAPC5
Entrez ID		10666	2587
HPRD ID		09252	02657
Ensembl ID		ENSG00000150637	ENSG00000166573
Uniprot IDs		J3QR77 Q15762	P47211
PDB IDs		6ISB 6O3O
Enriched GO Terms of Interacting Partners?
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