NPC2 and SCRN1

Data Source:
BioGRID (affinity chromatography technology)

		NPC2	SCRN1
Description		NPC intracellular cholesterol transporter 2	secernin 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Endoplasmic Reticulum Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome	Nucleus Cytoplasm Nuclear Membrane
	Molecular Function	Protein Binding Cholesterol Binding Enzyme Binding Sterol Binding Cholesterol Transfer Activity	Molecular_function Protein Binding Dipeptidase Activity Cysteine-type Exopeptidase Activity
	Biological Process	Cholesterol Metabolic Process Response To Virus Phospholipid Transport Sterol Transport Regulation Of Isoprenoid Metabolic Process Cholesterol Transport Intracellular Sterol Transport Intracellular Cholesterol Transport Cholesterol Efflux Low-density Lipoprotein Particle Clearance Cholesterol Homeostasis Neutrophil Degranulation Glycolipid Transport Intermembrane Lipid Transfer	Proteolysis Exocytosis
Pathways		Neutrophil degranulation LDL clearance
Drugs
Diseases		Niemann-Pick type C disease (NPC), including: Niemann-Pick disease, type C1; Niemann-Pick disease, type C2
GWAS		Advanced glycation end-product levels ( 26915486) Blood protein levels ( 29875488) Intraocular pressure ( 31959993) Refractive error ( 32231278)	Obesity-related traits ( 23251661) Psoriasis ( 25854761)
Interacting Genes		9 interacting genes: BARD1 BRCA1 DHDDS ECT2 ERRFI1 LIG4 PAXIP1 TRIM14 USP4	3 interacting genes: GORASP1 HGS ZNF25
Entrez ID		10577	9805
HPRD ID		03008	15304
Ensembl ID		ENSG00000119655	ENSG00000136193
Uniprot IDs		A0A024R6C0 P61916	A0A024RA21 A0A090N7T9 Q12765
PDB IDs		5KWY 6W5V
Enriched GO Terms of Interacting Partners?
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