NPC2 and SSR1

Data Source:
BioGRID (enzymatic study)

		NPC2	SSR1
Description		NPC intracellular cholesterol transporter 2	signal sequence receptor subunit 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Endoplasmic Reticulum Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Cholesterol Binding Enzyme Binding Sterol Binding Cholesterol Transfer Activity	Protein Binding
	Biological Process	Cholesterol Metabolic Process Response To Virus Phospholipid Transport Sterol Transport Regulation Of Isoprenoid Metabolic Process Cholesterol Transport Intracellular Sterol Transport Intracellular Cholesterol Transport Cholesterol Efflux Low-density Lipoprotein Particle Clearance Cholesterol Homeostasis Neutrophil Degranulation Glycolipid Transport Intermembrane Lipid Transfer	Cotranslational Protein Targeting To Membrane Positive Regulation Of Cell Population Proliferation IRE1-mediated Unfolded Protein Response
Pathways		Neutrophil degranulation LDL clearance	SRP-dependent cotranslational protein targeting to membrane XBP1(S) activates chaperone genes
Drugs
Diseases		Niemann-Pick type C disease (NPC), including: Niemann-Pick disease, type C1; Niemann-Pick disease, type C2
GWAS		Advanced glycation end-product levels ( 26915486) Blood protein levels ( 29875488) Intraocular pressure ( 31959993) Refractive error ( 32231278)	Brain morphology (MOSTest) ( 32665545) Ewing sarcoma ( 30093639) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes ( 24509480 32499647 30718926 28869590)
Interacting Genes		9 interacting genes: BARD1 BRCA1 DHDDS ECT2 ERRFI1 LIG4 PAXIP1 TRIM14 USP4	8 interacting genes: DKC1 EEF1A1 HSPA13 NUP54 ODC1 PTN SERPINF2 UTP14A
Entrez ID		10577	6745
HPRD ID		03008	02924
Ensembl ID		ENSG00000119655	ENSG00000124783
Uniprot IDs		A0A024R6C0 P61916	C9JBX5 P43307
PDB IDs		5KWY 6W5V
Enriched GO Terms of Interacting Partners?
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