NPC2 and CTSW

Data Source:
BioGRID (biochemical)

		NPC2	CTSW
Description		NPC intracellular cholesterol transporter 2	cathepsin W
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Endoplasmic Reticulum Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome	Extracellular Region Extracellular Space Lysosome Endoplasmic Reticulum Membrane Platelet Dense Granule Lumen
	Molecular Function	Protein Binding Cholesterol Binding Enzyme Binding Sterol Binding Cholesterol Transfer Activity	Cysteine-type Endopeptidase Activity Cysteine-type Peptidase Activity
	Biological Process	Cholesterol Metabolic Process Response To Virus Phospholipid Transport Sterol Transport Regulation Of Isoprenoid Metabolic Process Cholesterol Transport Intracellular Sterol Transport Intracellular Cholesterol Transport Cholesterol Efflux Low-density Lipoprotein Particle Clearance Cholesterol Homeostasis Neutrophil Degranulation Glycolipid Transport Intermembrane Lipid Transfer	Platelet Degranulation Immune Response Proteolysis Involved In Cellular Protein Catabolic Process
Pathways		Neutrophil degranulation LDL clearance	Platelet degranulation
Drugs
Diseases		Niemann-Pick type C disease (NPC), including: Niemann-Pick disease, type C1; Niemann-Pick disease, type C2
GWAS		Advanced glycation end-product levels ( 26915486) Blood protein levels ( 29875488) Intraocular pressure ( 31959993) Refractive error ( 32231278)	Acne (severe) ( 24927181) Asthma ( 31959851) Inflammatory bowel disease ( 23128233)
Interacting Genes		9 interacting genes: BARD1 BRCA1 DHDDS ECT2 ERRFI1 LIG4 PAXIP1 TRIM14 USP4	1 interacting genes: CREB3
Entrez ID		10577	1521
HPRD ID		03008	03840
Ensembl ID		ENSG00000119655	ENSG00000172543
Uniprot IDs		A0A024R6C0 P61916	P56202
PDB IDs		5KWY 6W5V
Enriched GO Terms of Interacting Partners?
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