PITRM1 and SOCS6

Data Source:
BioGRID (genetic interference)

		PITRM1	SOCS6
Description		pitrilysin metallopeptidase 1	suppressor of cytokine signaling 6
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Immunological Synapse Cytoplasm Cytosol Phosphatidylinositol 3-kinase Complex
	Molecular Function	Metalloendopeptidase Activity Enzyme Activator Activity Metallopeptidase Activity Zinc Ion Binding	Protein Binding 1-phosphatidylinositol-3-kinase Regulator Activity
	Biological Process	Proteolysis Protein Targeting To Mitochondrion Protein Processing Regulation Of Catalytic Activity	Defense Response Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Signal Transduction Proteasomal Protein Catabolic Process Protein Ubiquitination Intracellular Signal Transduction Regulation Of Growth Regulation Of Phosphatidylinositol 3-kinase Activity Post-translational Protein Modification Phosphatidylinositol Phosphorylation Negative Regulation Of T Cell Activation
Pathways		Mitochondrial protein import	Regulation of KIT signaling Neddylation Negative regulation of FLT3
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Metabolite levels ( 23823483) Scalp hair shape ( 26926045)	Diverticular disease ( 30177863) Night sleep phenotypes ( 27126917) Systemic lupus erythematosus ( 18204098) Type 2 diabetes ( 29621232)
Interacting Genes			39 interacting genes: ACVR1 AMOT APPL1 AR BMPR1B C1orf109 CLNK CRK DAB1 EFEMP1 EGFR ELOB ELOC ERBB2 ERBB3 ERBB4 FRS3 GAB1 INSR IRS2 IRS4 KDM1A KIT LNX1 MET PIK3R1 PIK3R2 PIK3R3 RBCK1 RELA SMURF2 TGFBR1 TUBA1A TUBB4B TXK UBE2D2 UBE2I WDR89 ZMIZ2
Entrez ID		10531	9306
HPRD ID		07142	05491
Ensembl ID		ENSG00000107959	ENSG00000170677
Uniprot IDs		Q5JRX3	A0A024R379 O14544
PDB IDs		4L3T 4NGE 4RPU	2VIF
Enriched GO Terms of Interacting Partners?
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