MYL9 and CEP250

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		MYL9	CEP250
Description		myosin light chain 9	centrosomal protein 250
Image		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cytosol Muscle Myosin Complex Z Disc	Photoreceptor Outer Segment Photoreceptor Inner Segment Centrosome Centriole Microtubule Organizing Center Cytosol Protein-containing Complex Ciliary Basal Body Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Calcium Ion Binding Structural Constituent Of Muscle Myosin Heavy Chain Binding	Protein Binding Protein C-terminus Binding Protein Kinase Binding Protein Domain Specific Binding
	Biological Process	Muscle Contraction Regulation Of Muscle Contraction Regulation Of Megakaryocyte Differentiation Platelet Aggregation	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Localization Regulation Of G2/M Transition Of Mitotic Cell Cycle Centriole-centriole Cohesion Regulation Of Centriole-centriole Cohesion Protein Localization To Organelle Detection Of Light Stimulus Involved In Visual Perception Cilium Assembly Ciliary Basal Body-plasma Membrane Docking Positive Regulation Of Protein Localization To Centrosome Non-motile Cilium Assembly
Pathways		EPHA-mediated growth cone collapse Sema4D induced cell migration and growth-cone collapse Smooth Muscle Contraction RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS			Amyotrophic lateral sclerosis (sporadic) ( 24529757) Brain morphology (MOSTest) ( 32665545) Height ( 25429064 18391951) Refractive error ( 32231278) Ulcerative colitis ( 23128233) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		6 interacting genes: CDC42BPA HSPB1 LRRK2 MSGN1 MYH9 TXN2	6 interacting genes: APP ATF7IP KAT2B NEK2 PLEKHA5 YWHAG
Entrez ID		10398	11190
HPRD ID		17619	09877
Ensembl ID		ENSG00000101335	ENSG00000126001
Uniprot IDs		A0A384NY64 P24844	Q9BV73
PDB IDs			6OQA
Enriched GO Terms of Interacting Partners?
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