SLC17A2 and NEU1

Data Source:
BioGRID (affinity chromatography technology)

		SLC17A2	NEU1
Description		solute carrier family 17 member 2	neuraminidase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lysosome Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane	Extracellular Region Cytoplasm Lysosome Lysosomal Membrane Plasma Membrane Membrane Cell Junction Specific Granule Lumen Lysosomal Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Sodium:phosphate Symporter Activity Sialic Acid Transmembrane Transporter Activity Transmembrane Transporter Activity	Exo-alpha-sialidase Activity Protein Binding Alpha-sialidase Activity Exo-alpha-(2->3)-sialidase Activity Exo-alpha-(2->6)-sialidase Activity Exo-alpha-(2->8)-sialidase Activity
	Biological Process	Phosphate-containing Compound Metabolic Process Sodium Ion Transport Anion Transport Sialic Acid Transport Sodium Ion Transmembrane Transport	Glycosphingolipid Metabolic Process Ganglioside Catabolic Process Oligosaccharide Catabolic Process Neutrophil Degranulation
Pathways			Glycosphingolipid metabolism Sialic acid metabolism Defective NEU1 causes sialidosis Neutrophil degranulation
Drugs			Oseltamivir
Diseases			Sialidosis; Mucolipidosis I Galactosialidosis Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Blood pressure ( 24954895) Brain morphology (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) Height ( 25429064) Hemoglobin levels ( 32327693) Iron status biomarkers (total iron binding capacity) ( 28334935) LDL cholesterol ( 30275531) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Oily fish consumption ( 32066663) Red cell distribution width ( 32888494 27863252 28957414) Refractive error ( 32231278) Serum uric acid levels ( 32514006) Subcortical volume (MOSTest) ( 32665545)	Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Basal cell carcinoma ( 27539887) Blood protein levels ( 28240269) Estimated glomerular filtration rate ( 31152163) Inflammatory bowel disease ( 28067908) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Small cell lung carcinoma ( 28604730) Squamous cell lung carcinoma ( 28604730) Ulcerative colitis ( 28067908)
Interacting Genes			29 interacting genes: AQP6 CCR9 CD79A CERS3 CERS4 CREB3 CREB3L1 CTSA EBP EEF1A1 ERGIC3 ERRFI1 GLB1 GOLM1 GPR152 GPX8 HSD17B11 JUNB KCNA2 KCNA4 LIG4 LMNA MGST3 MUC1 SLC10A1 SLC10A6 SLC18A1 SLC39A9 TMEM14B
Entrez ID		10246	4758
HPRD ID		10232	09751
Ensembl ID		ENSG00000112337	ENSG00000204386
Uniprot IDs		A0A024QZY2 O00624	Q5JQI0 Q99519
PDB IDs
Enriched GO Terms of Interacting Partners?
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