ANGPTL7 and TNFRSF14

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		ANGPTL7	TNFRSF14
Description		angiopoietin like 7	TNF receptor superfamily member 14
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Collagen-containing Extracellular Matrix	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Identical Protein Binding	Virus Receptor Activity Tumor Necrosis Factor-activated Receptor Activity Protein Binding Cytokine Binding Ubiquitin Protein Ligase Binding
	Biological Process	Angiogenesis Response To Oxidative Stress Negative Regulation Of Vasculature Development Involved In Avascular Cornea Development In Camera-type Eye Regulation Of Extracellular Matrix Organization	Adaptive Immune Response Positive Regulation Of Cytokine Production Involved In Immune Response Immune Response Cell Surface Receptor Signaling Pathway T Cell Costimulation Tumor Necrosis Factor-mediated Signaling Pathway Innate Immune Response Negative Regulation Of Alpha-beta T Cell Proliferation Viral Entry Into Host Cell Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Negative Regulation Of Adaptive Immune Memory Response Positive Regulation Of T Cell Migration
Pathways			Costimulation by the CD28 family Costimulation by the CD28 family TNFs bind their physiological receptors
Drugs
Diseases
GWAS		Beard thickness ( 26926045) Intraocular pressure ( 29617998)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Autoimmune thyroid disease ( 32581359) Body mass index ( 26426971) Celiac disease ( 20190752) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Inflammatory bowel disease ( 28067908) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 28445677) Primary sclerosing cholangitis ( 23603763) Rheumatoid arthritis ( 24449572 30423114 18794853 24390342 20453842) Ulcerative colitis ( 28067908 26398853 23128233 21297633)
Interacting Genes		3 interacting genes: ACTN2 APP FBXO7	30 interacting genes: A2M APP BTLA CD160 CEP126 CHD3 DGKD DRAP1 DYNLL1 ESR1 HDAC3 HDAC4 IMPA2 ITFG1 LTA MBTPS1 NDUFS2 NRIP1 RAD21 SERPINA4 TNFSF13 TNFSF14 TRAF1 TRAF2 TRAF3 TRAF5 UBQLN4 VIM WDR73 ZBTB48
Entrez ID		10218	8764
HPRD ID		10818	04122
Ensembl ID		ENSG00000171819	ENSG00000157873
Uniprot IDs		O43827	A0A024R052 Q92956
PDB IDs			1JMA 2AW2 4FHQ 4RSU 5T2Q 5T2R 6NG3
Enriched GO Terms of Interacting Partners?
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