ZNF197 and GPX4

Data Source:
HPRD (in vitro)

		ZNF197	GPX4
Description		zinc finger protein 197	glutathione peroxidase 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Mitochondrion Cytosol Protein-containing Complex Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Metal Ion Binding	Peroxidase Activity Glutathione Peroxidase Activity Protein Binding Identical Protein Binding Phospholipid-hydroperoxide Glutathione Peroxidase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II	Phospholipid Metabolic Process Response To Oxidative Stress Multicellular Organism Development Spermatogenesis Arachidonic Acid Metabolic Process Lipoxygenase Pathway Long-chain Fatty Acid Biosynthetic Process Protein Polymerization Cellular Oxidant Detoxification Negative Regulation Of Ferroptosis
Pathways		Generic Transcription Pathway	Synthesis of 5-eicosatetraenoic acids Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of 15-eicosatetraenoic acid derivatives
Drugs			Glutathione Glutathione Glutathione disulfide
Diseases
GWAS			Advanced age-related macular degeneration ( 26691988) Asthma (childhood onset) ( 31036433) Basal cell carcinoma ( 31174203) Crohn's disease ( 28067908 21102463 23128233) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Inflammatory bowel disease ( 28067908) Keratinocyte cancer (MTAG) ( 31174203) Nasal polyps ( 30643255) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 32888494)
Interacting Genes		5 interacting genes: DISC1 HSPB1 NDEL1 TRIM28 VHL	3 interacting genes: MAPK13 PARK7 PRDX6
Entrez ID		10168	2879
HPRD ID		10322	11819
Ensembl ID		ENSG00000186448	ENSG00000167468
Uniprot IDs		O14709 Q7Z6G1	P36969 Q6PI42
PDB IDs			2GS3 2OBI 5H5Q 5H5R 5H5S 6ELW 6HKQ 6HN3
Enriched GO Terms of Interacting Partners?
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