RASGRP1 and MGA

Data Source:
BioGRID (affinity chromatography technology)

		RASGRP1	MGA
Description		RAS guanyl releasing protein 1	MAX dimerization protein MGA
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Membrane	Chromatin Nucleoplasm MLL1 Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Zinc Ion Binding Lipid Binding Diacylglycerol Binding Phosphatidylcholine Binding Identical Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Protein Dimerization Activity
	Biological Process	MAPK Cascade Positive Regulation Of Protein Phosphorylation Signal Transduction Ras Protein Signal Transduction Natural Killer Cell Activation Cell Differentiation Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Tumor Necrosis Factor Production T Cell Proliferation B Cell Proliferation T Cell Activation B Cell Activation Positive Regulation Of MAP Kinase Activity Positive Regulation Of GTPase Activity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of JNK Cascade Positive Regulation Of Ras Protein Signal Transduction Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Activation Of GTPase Activity Regulation Of Phospholipase C Activity Regulation Of P38MAPK Cascade	Cell Fate Specification Regulation Of Transcription By RNA Polymerase II Negative Regulation Of G0 To G1 Transition
Pathways		Effects of PIP2 hydrolysis Activation of RAS in B cells Activation of RAS in B cells FCERI mediated NF-kB activation Integrin signaling Rap1 signalling RAF/MAP kinase cascade	Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Autoimmune traits (pleiotropy) ( 30572963) Bipolar disorder ( 18711365) Carboplatin disposition in epthelial ovarian cancer ( 29367611) Crohn's disease ( 28067908 23128233) Estimated glomerular filtration rate ( 30604766) Medication use (thyroid preparations) ( 31015401) Metabolite levels ( 23823483) Multiple sclerosis ( 24076602) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701) Psychosis (atypical) ( 24132900) Rheumatoid arthritis ( 30423114 30572963 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Systemic lupus erythematosus ( 28714469) Type 1 diabetes ( 21829393 25751624 18840781) Type 2 diabetes ( 30297969 28254843 22961080 32499647 30718926)	Feeling nervous ( 29500382) Lung function (FEV1/FVC) ( 28166213 30804560) Mean spheric corpuscular volume ( 32888494) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		2 interacting genes: DGKZ HRAS	9 interacting genes: CBX3 E2F1 E2F3 E2F4 H3-4 LSM8 MAX SMAD1 TULP3
Entrez ID		10125	23269
HPRD ID		04909	19055
Ensembl ID		ENSG00000172575	ENSG00000174197
Uniprot IDs		B2RA89 O95267	Q8IWI9
PDB IDs		4L9M 4L9U
Enriched GO Terms of Interacting Partners?
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