RASGRP1 and DNAH8

Data Source:
BioGRID (proximity labelling technology)

		RASGRP1	DNAH8
Description		RAS guanyl releasing protein 1	dynein axonemal heavy chain 8
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Membrane	Axonemal Dynein Complex Microtubule Axoneme Dynein Complex Sperm Flagellum Outer Dynein Arm
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Zinc Ion Binding Lipid Binding Diacylglycerol Binding Phosphatidylcholine Binding Identical Protein Binding	Microtubule Motor Activity ATP Binding ATP-dependent Microtubule Motor Activity, Minus-end-directed Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding
	Biological Process	MAPK Cascade Positive Regulation Of Protein Phosphorylation Signal Transduction Ras Protein Signal Transduction Natural Killer Cell Activation Cell Differentiation Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Tumor Necrosis Factor Production T Cell Proliferation B Cell Proliferation T Cell Activation B Cell Activation Positive Regulation Of MAP Kinase Activity Positive Regulation Of GTPase Activity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of JNK Cascade Positive Regulation Of Ras Protein Signal Transduction Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Activation Of GTPase Activity Regulation Of Phospholipase C Activity Regulation Of P38MAPK Cascade	Microtubule-based Movement Outer Dynein Arm Assembly Cilium-dependent Cell Motility
Pathways		Effects of PIP2 hydrolysis Activation of RAS in B cells Activation of RAS in B cells FCERI mediated NF-kB activation Integrin signaling Rap1 signalling RAF/MAP kinase cascade
Drugs
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Autoimmune traits (pleiotropy) ( 30572963) Bipolar disorder ( 18711365) Carboplatin disposition in epthelial ovarian cancer ( 29367611) Crohn's disease ( 28067908 23128233) Estimated glomerular filtration rate ( 30604766) Medication use (thyroid preparations) ( 31015401) Metabolite levels ( 23823483) Multiple sclerosis ( 24076602) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701) Psychosis (atypical) ( 24132900) Rheumatoid arthritis ( 30423114 30572963 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Systemic lupus erythematosus ( 28714469) Type 1 diabetes ( 21829393 25751624 18840781) Type 2 diabetes ( 30297969 28254843 22961080 32499647 30718926)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Circulating leptin levels in high cardiovascular risk ( 31766143) Smoking status (heavy vs never) ( 26423011)
Interacting Genes		2 interacting genes: DGKZ HRAS
Entrez ID		10125	1769
HPRD ID		04909	04515
Ensembl ID		ENSG00000172575	ENSG00000124721
Uniprot IDs		B2RA89 O95267	A0A075B6F3 Q8IU65 Q96JB1
PDB IDs		4L9M 4L9U
Enriched GO Terms of Interacting Partners?
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