ACTR1A and CNNM2

Data Source:
BioGRID (affinity chromatography technology)

		ACTR1A	CNNM2
Description		actin related protein 1A	cyclin and CBS domain divalent metal cation transport mediator 2
Image		No pdb structure
GO Annotations	Cellular Component	Manchette Cytoplasm Centrosome Centriole Cytosol Dynactin Complex Microtubule Associated Complex Microtubule Cytoskeleton COPI-coated Vesicle Extracellular Exosome Cell Cortex Region	Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding ATP Binding	ATP Binding Magnesium Ion Transmembrane Transporter Activity Transmembrane Transporter Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Spermatogenesis Regulation Of G2/M Transition Of Mitotic Cell Cycle Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Ciliary Basal Body-plasma Membrane Docking	Transport Magnesium Ion Homeostasis Magnesium Ion Transmembrane Transport
Pathways		MHC class II antigen presentation Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic AURKA Activation by TPX2
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Prostate cancer ( 23535732) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Anxiety/tension (special factor of neuroticism) ( 30867560) Arsenic metabolism ( 22383894) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blood pressure ( 21572416) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778 24262325 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 21378990) Creatine kinase levels ( 29403010) Diastolic blood pressure ( 30487518) Estimated glomerular filtration rate ( 31015462) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hypertension ( 31879980 30487518) Intracranial aneurysm ( 20364137) Mean arterial pressure ( 27618448 30487518) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494 27863252) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Microalbuminuria ( 26631737) Myocardial infarction ( 26343387) Number of sexual partners ( 30643258) Parkinson's disease ( 19915575) Prostate cancer ( 23535732) Pulse pressure ( 30487518) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494) Schizophrenia ( 28991256 25056061 21926974 29483656 22688191 30285260 23974872 23894747) Smoking initiation ( 30617275) Systolic blood pressure ( 19430483 30487518 30578418) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) White blood cell count ( 32888494) White matter lesion progression ( 26451028)
Interacting Genes		5 interacting genes: DCTN1 DCTN4 NUMA1 SPTBN1 SPTBN2
Entrez ID		10121	54805
HPRD ID		05507	07418
Ensembl ID		ENSG00000138107	ENSG00000148842
Uniprot IDs		A0A384NQ21 P61163	Q9H8M5
PDB IDs			4IY0 4IY2 4IY4 4IYS 6DJ3 6N7E
Enriched GO Terms of Interacting Partners?
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