KCNE2

Description		potassium voltage-gated channel subfamily E regulatory subunit 2
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GO Annotations	Cellular Component	Lysosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface
	Molecular Function	Inward Rectifier Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity Identical Protein Binding Ion Channel Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Aging Cellular Response To Drug Tongue Development Regulation Of Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cardiac Conduction Potassium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization Membrane Repolarization During Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Inward Rectifier Potassium Channel Activity Regulation Of Cyclic Nucleotide-gated Ion Channel Activity Regulation Of Delayed Rectifier Potassium Channel Activity Negative Regulation Of Delayed Rectifier Potassium Channel Activity Potassium Ion Import Across Plasma Membrane
Pathways		Phase 3 - rapid repolarisation Phase 2 - plateau phase
Drugs		Enflurane Promethazine Miconazole
Diseases		Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS) Atrial fibrillation
GWAS		Body mass index (smoking years interaction) ( 23192594) Cancer ( 29299148) Chronic obstructive pulmonary disease ( 30804561) Coronary artery disease ( 32469254 24262325 30104761 26343387 28714974 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Heel bone mineral density ( 30598549 28869591) Height ( 20881960 31562340) Joint mobility (Beighton score) ( 27182965) Lung function (FEV1/FVC) ( 28166213 30804560) Myocardial infarction ( 26708285 26343387) Myocardial infarction (early onset) ( 19198609) Pulmonary function ( 21946350)
Interacting Genes		2 interacting genes: KCNH2 KCNQ1
Entrez ID		9992
HPRD ID		04813
Ensembl ID		ENSG00000159197
Uniprot IDs		Q9Y6J6
PDB IDs		2M0Q
Enriched GO Terms of Interacting Partners?
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