ADAMTS2

Description		ADAM metallopeptidase with thrombospondin type 1 motif 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Matrix Collagen-containing Extracellular Matrix
	Molecular Function	Metalloendopeptidase Activity Metallopeptidase Activity Zinc Ion Binding
	Biological Process	Spermatogenesis Protein Processing Extracellular Matrix Organization Collagen Fibril Organization Lung Development Collagen Catabolic Process Skin Development
Pathways		Collagen biosynthesis and modifying enzymes Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
Drugs
Diseases		Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)
GWAS		Attention deficit hyperactivity disorder (time to onset) ( 18937294) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Central corneal thickness ( 29760442) Depression in response to interferon-based therapy in chronic hepatitis C ( 27723809) Height ( 25282103) Intake of total sugars ( 31005972) Intraocular pressure ( 29617998 31798171) Intraocular pressure and central corneal thickness (multi-trait analysis) ( 31798171) Refractive astigmatism ( 30306274) Stroke (pediatric) ( 22990015) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		1 interacting genes: PIK3R1
Entrez ID		9509
HPRD ID		05173
Ensembl ID		ENSG00000087116
Uniprot IDs		O95450
PDB IDs
Enriched GO Terms of Interacting Partners?
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