ADAMTS3

Description		ADAM metallopeptidase with thrombospondin type 1 motif 3
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Protein Binding Heparin Binding Zinc Ion Binding
	Biological Process	In Utero Embryonic Development Vascular Endothelial Growth Factor Production Protein Processing Extracellular Matrix Organization Collagen Fibril Organization Collagen Catabolic Process Collagen Biosynthetic Process Supramolecular Fiber Organization Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Pathways		Collagen biosynthesis and modifying enzymes Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cholesterol ester levels in large LDL ( 29084231) Cholesterol ester levels in medium LDL ( 29084231) Cholesterol, total ( 25961943) Coronary artery disease ( 33020668) Cortical surface area (MOSTest) ( 32665545) Dental caries ( 23259602) Dialysis-related mortality ( 21546767) Glycine levels ( 31070104) Height ( 28552196 20881960 25282103 25429064 31562340) Hip circumference adjusted for BMI ( 25673412) Hippocampal volume ( 29274321) Hippocampal volume in mild cognitive impairment ( 29274321) Large LDL particle concentration ( 29084231) Medium LDL particle concentration ( 29084231) Metabolite levels ( 22916037) Serum total cholesterol levels ( 29084231) Small LDL particle concentration ( 29084231) Subcortical volume (MOSTest) ( 32665545) Total cholesterol levels in large LDL ( 29084231) Total cholesterol levels in LDL ( 29084231) Total cholesterol levels in medium LDL ( 29084231) Total cholesterol levels in small LDL ( 29084231) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 26785701 28448500)
Interacting Genes		1 interacting genes: UBQLN2
Entrez ID		9508
HPRD ID		06893
Ensembl ID		ENSG00000156140
Uniprot IDs		B7Z2U9 O15072 Q96AY5
PDB IDs
Enriched GO Terms of Interacting Partners?
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