RPL23

Description		ribosomal protein L23
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GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Cytosol Ribosome Focal Adhesion Postsynaptic Density Membrane Cytosolic Large Ribosomal Subunit Protein-containing Complex Extracellular Exosome
	Molecular Function	Transcription Coactivator Binding RNA Binding Structural Constituent Of Ribosome Protein Binding Ubiquitin Protein Ligase Binding Large Ribosomal Subunit RRNA Binding Ubiquitin Ligase Inhibitor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Initiation Ribosomal Protein Import Into Nucleus SRP-dependent Cotranslational Protein Targeting To Membrane Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Viral Transcription Protein-DNA Complex Disassembly Protein Stabilization Negative Regulation Of Cell Cycle Arrest Positive Regulation Of Cell Cycle Arrest Cellular Response To Actinomycin D Positive Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Ubiquitin Protein Ligase Activity Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs		(S)-3-phenyllactic acid Anisomycin Puromycin
Diseases
GWAS		Chronic obstructive pulmonary disease ( 30804561)
Interacting Genes		12 interacting genes: APP BCCIP CDC42 CLU DAPP1 DUX4 EPS8L2 GRWD1 IPO5 MEOX2 PTEN RELA
Entrez ID		9349
HPRD ID		04716
Ensembl ID		ENSG00000125691
Uniprot IDs		A0A024R1Q8 P62829
PDB IDs		4UG0 4V6X 5AJ0 5LKS 5T2C 6EK0 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO
Enriched GO Terms of Interacting Partners?
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