TBXAS1

Description		thromboxane A synthase 1
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Monooxygenase Activity Thromboxane-A Synthase Activity Iron Ion Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Heme Binding 12-hydroxyheptadecatrienoic Acid Synthase Activity Hydroperoxy Icosatetraenoate Dehydratase Activity
	Biological Process	Prostaglandin Biosynthetic Process Icosanoid Metabolic Process Cyclooxygenase Pathway
Pathways		Eicosanoids Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)
Drugs		Sulfasalazine Ridogrel Dazoxiben NM-702
Diseases		Diaphyseal dysplasia with anemia (Ghosal)
GWAS		Acute lymphoblastic leukemia (childhood) ( 23007406) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Cerebellum growth ( 29682794) Cervical cancer ( 28806749) Coronary artery disease ( 29212778 33020668) Gray matter volume (schizophrenia interaction) ( 24086445) Heel bone mineral density ( 30598549) Height ( 31217584) Late-onset Alzheimer's disease ( 27770636) Obesity-related traits ( 23251661) Systolic blood pressure ( 30578418) White blood cell count ( 32888494)
Interacting Genes		1 interacting genes: UBC
Entrez ID		6916
HPRD ID		02035
Ensembl ID		ENSG00000059377
Uniprot IDs		A0A0A0MSK3 A0A0C4DH47 B4DVP1 P24557 Q53F23
PDB IDs
Enriched GO Terms of Interacting Partners?
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