AKR1D1

Description		aldo-keto reductase family 1 member D1
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GO Annotations	Cellular Component	Cytosol
	Molecular Function	Alditol:NADP+ 1-oxidoreductase Activity Aldo-keto Reductase (NADP) Activity Steroid Binding Steroid Dehydrogenase Activity Ketosteroid Monooxygenase Activity Delta4-3-oxosteroid 5beta-reductase Activity
	Biological Process	Bile Acid Biosynthetic Process Cholesterol Catabolic Process Digestion Steroid Metabolic Process C21-steroid Hormone Metabolic Process Androgen Metabolic Process Bile Acid Catabolic Process
Pathways		Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol
Drugs		Azelaic acid Finasteride 5beta-dihydrotestosterone 3,20-Pregnanedione
Diseases		Congenital bile acid synthesis defect (CBAS), including: 3-beta-hydroxy-delta-5-C27-steroid oxidoreductase deficiency (CBAS1); Delta(4)-3-oxosteroid 5-beta-reductase deficiency (CBAS2); Oxysterol 7-alpha-hydroxylase deficiency (CBAS3); Alpha-methylacyl-CoA racemase deficiency (CBAS4)
GWAS		Bipolar disorder with mood-incongruent psychosis ( 23092984) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) C-reactive protein levels in ischemic stroke ( 26718567) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)
Novel Interacting Genes		1 novel interacting genes: MRPS33
Interacting Genes
Entrez ID		6718
HPRD ID		07263
Ensembl ID		ENSG00000122787
Uniprot IDs		P51857
PDB IDs		3BUR 3BUV 3BV7 3CAQ 3CAS 3CAV 3CMF 3COT 3DOP 3G1R 3UZW 3UZX 3UZY 3UZZ
Enriched GO Terms of Interacting Partners?
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