SCN1A

Description		sodium voltage-gated channel alpha subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Nucleoplasm Plasma Membrane Nuclear Body Z Disc Axon
	Molecular Function	Voltage-gated Ion Channel Activity Voltage-gated Sodium Channel Activity
	Biological Process	Sodium Ion Transport Neuronal Action Potential Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Depolarization During Action Potential
Pathways		Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation
Drugs		Ranolazine Phenytoin Topiramate Valproic acid Lamotrigine Carbamazepine Oxcarbazepine Cocaine Zonisamide Promethazine Phenacemide Phenazopyridine Nitrazepam Permethrin Tetrodotoxin Brivaracetam Tetracaine Amylocaine Propoxycaine Pramocaine Pentoxyverine Dichlorobenzyl alcohol Bioallethrin Fish oil
Diseases		Febrile seizures, including: Febrile convulsions; Generalized epilepsy with febrile seizure plus (GEFS+); Dravet syndrome/ Severe myoclonic epilepsy in infancy (SMEI) Familial or sporadic hemiplegic migraine
GWAS		Epilepsy ( 25087078 30531953) Febrile seizures ( 25344690) Febrile seizures (MMR vaccine-related) ( 25344690) Febrile seizures (MMR vaccine-unrelated) ( 25344690) Focal epilepsy ( 30531953) Generalized epilepsy ( 30531953 22949513) Mesial temporal lobe epilepsy with hippocampal sclerosis ( 24014518) Whole brain grey matter density ( 31530798)
Novel Interacting Genes		1 novel interacting genes: NAB2
Interacting Genes		2 interacting genes: PSEN1 SNTA1
Entrez ID		6323
HPRD ID		01669
Ensembl ID		ENSG00000144285
Uniprot IDs		P35498
PDB IDs
Enriched GO Terms of Interacting Partners?
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