NLRC4

Description		NLR family CARD domain containing 4
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GO Annotations	Cellular Component	Cytosol IPAF Inflammasome Complex
	Molecular Function	Magnesium Ion Binding Protein Binding ATP Binding Identical Protein Binding Protein Homodimerization Activity Endopeptidase Activator Activity Caspase Binding
	Biological Process	Activation Of Innate Immune Response Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Positive Regulation Of Protein Processing Detection Of Bacterium Positive Regulation Of Interleukin-1 Beta Production Defense Response To Bacterium Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Pyroptosis Activation Of Cysteine-type Endopeptidase Activity
Pathways		TP53 Regulates Transcription of Caspase Activators and Caspases The IPAF inflammasome The IPAF inflammasome
Drugs
Diseases
GWAS		Blood protein levels in cardiovascular risk ( 28369058) Inflammatory biomarkers ( 24182552) Interleukin-18 levels ( 27989323 31584380) Male-pattern baldness ( 28196072)
Novel Interacting Genes		1 novel interacting genes: ALK
Interacting Genes		5 interacting genes: BCL10 CASP1 NLRP4 NOD2 PYCARD
Entrez ID		58484
HPRD ID		06014
Ensembl ID		ENSG00000091106
Uniprot IDs		Q9NPP4
PDB IDs		6K8J 6MKS 6N1I
Enriched GO Terms of Interacting Partners?
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