RTEL1

Description		regulator of telomere elongation helicase 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm
	Molecular Function	DNA Binding DNA Helicase Activity Protein Binding ATP Binding Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding DNA Polymerase Binding
	Biological Process	Telomere Maintenance Strand Displacement DNA Repair Regulation Of Double-strand Break Repair Via Homologous Recombination Replication Fork Processing Positive Regulation Of Telomere Maintenance DNA Duplex Unwinding Telomere Maintenance In Response To DNA Damage Negative Regulation Of DNA Recombination Telomeric Loop Disassembly Mitotic Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Telomere Capping Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of T-circle Formation Negative Regulation Of Telomere Maintenance In Response To DNA Damage Positive Regulation Of Telomeric Loop Disassembly
Pathways		Telomere Extension By Telomerase Cytosolic iron-sulfur cluster assembly Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Drugs
Diseases
GWAS		Adult diffuse glioma (IDH wildtype) ( 32386320) Adult diffuse glioma (TERT mutation only) ( 32386320) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Anorectal malformation ( 31136621) Asthma ( 31361310 30929738 32296059 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 26482879) Crohn's disease ( 28067908 21102463) Cutaneous malignant melanoma ( 32341527 26237428) Dental caries ( 23259602) Eczema ( 31361310) Glioblastoma ( 28346443 29743610) Glioblastoma (age-stratified) ( 30152087) Glioma ( 30714141 28346443 21531791 22886559 29743610 19578367) Glioma (high-grade) ( 24908248 19578366) Idiopathic pulmonary fibrosis ( 31710517) Inflammatory bowel disease ( 28067908) Leukocyte telomere length ( 32109421 31171785) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Nevus count or cutaneous melanoma ( 32341527) Non-glioblastoma glioma ( 28346443 29743610) Plateletcrit ( 32888494 27863252) Prostate cancer ( 23535732) Refractive error ( 32231278) Telomere length ( 29151059) Ulcerative colitis ( 28067908 21297633)
Novel Interacting Genes		1 novel interacting genes: RAE1
Interacting Genes
Entrez ID		51750
HPRD ID		15281
Ensembl ID		ENSG00000258366
Uniprot IDs		Q9NZ71 R4IXY3
PDB IDs
Enriched GO Terms of Interacting Partners?
Tagcloud ?