PDE1A

Description		phosphodiesterase 1A
Image
GO Annotations	Cellular Component	Nucleus Cytosol Neuronal Cell Body
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity Calmodulin-dependent Cyclic-nucleotide Phosphodiesterase Activity Calmodulin Binding Metal Ion Binding Calcium- And Calmodulin-regulated 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Regulation Of Smooth Muscle Cell Apoptotic Process CGMP Catabolic Process Regulation Of Smooth Muscle Cell Proliferation
Pathways		Cam-PDE 1 activation cGMP effects G alpha (s) signalling events
Drugs		Caffeine Nicardipine Felodipine Bepridil Trapidil
Diseases
GWAS		Alzheimer's disease in APOE e4+ carriers ( 25778476) Blood urea nitrogen levels ( 31152163) Diastolic blood pressure ( 28135244 27841878 30487518) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Estimated glomerular filtration rate ( 31152163 31451708) Intelligence (MTAG) ( 29326435) Mean arterial pressure ( 30487518) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Night sleep phenotypes ( 27126917) Pulmonary arterial hypertension ( 29088834) Pulse pressure ( 30578418) Response to platinum-based chemotherapy (carboplatin) ( 21844884) Urate levels ( 31578528)
Interacting Genes		3 interacting genes: APOA1 APP CALM1
Entrez ID		5136
HPRD ID		01387
Ensembl ID		ENSG00000115252
Uniprot IDs		B7Z226 B7Z7A2 P54750 Q9Y633
PDB IDs		1LXQ
Enriched GO Terms of Interacting Partners?
Tagcloud ?