NPR3

Description		natriuretic peptide receptor 3
Image
GO Annotations	Cellular Component	Integral Component Of Plasma Membrane Protein-containing Complex Extracellular Exosome
	Molecular Function	Protein Binding G Protein-coupled Peptide Receptor Activity Natriuretic Peptide Receptor Activity Peptide Hormone Binding Chloride Ion Binding Peptide Binding Hormone Binding Protein Homodimerization Activity
	Biological Process	Skeletal System Development Osteoclast Proliferation Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Blood Pressure Pancreatic Juice Secretion Regulation Of Osteoblast Proliferation Positive Regulation Of Urine Volume Phosphatidylinositol-mediated Signaling Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Cold-induced Thermogenesis
Pathways
Drugs		Nesiritide
Diseases
GWAS		Blood pressure ( 24954895 21572416 21909110) Diastolic blood pressure ( 26390057 27841878 21909115 28739976 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 28552196 20881960 25282103 19343178 23563607 31562340 28270201 19570815) Hip circumference adjusted for BMI ( 25673412) Hypertension ( 31879980 21909115) Mean arterial pressure ( 26390057 29403010 30487518) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Ovarian reserve ( 22116950) Pulse pressure ( 27841878 28739976 30578418) Pulse pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure ( 26390057 28135244 27841878 21909115 29403010 28739976 27618447 27618452 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500)
Novel Interacting Genes		3 novel interacting genes: NFKBIE NSD1 SLC30A9
Interacting Genes		3 interacting genes: NPPA NPPB NPPC
Entrez ID		4883
HPRD ID		00167
Ensembl ID		ENSG00000113389
Uniprot IDs		A8K4A5 P17342 Q60I31
PDB IDs		1JDN 1JDP 1YK0 1YK1
Enriched GO Terms of Interacting Partners?
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