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MYB
Description
MYB proto-oncogene, transcription factor
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytosol
Nuclear Matrix
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Mitotic Cell Cycle
Response To Hypoxia
Chromatin Remodeling
Regulation Of Transcription, DNA-templated
Positive Regulation Of Collagen Biosynthetic Process
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of T-helper Cell Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Histone H3-K4 Methylation
Positive Regulation Of Histone H3-K9 Methylation
Positive Regulation Of Glial Cell Proliferation
Cellular Response To Hydrogen Peroxide
Cellular Response To Retinoic Acid
Positive Regulation Of Transforming Growth Factor Beta Production
Regulation Of Hematopoietic Stem Cell Differentiation
Positive Regulation Of Hepatic Stellate Cell Proliferation
Positive Regulation Of Hepatic Stellate Cell Activation
Positive Regulation Of Testosterone Secretion
Pathways
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Transcriptional regulation of granulopoiesis
Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS
Aspartate aminotransferase levels (
29403010
)
Basophil count (
32888494
)
Basophil percentage of granulocytes (
27863252
)
Basophil percentage of white cells (
32888494
27863252
)
Beta thalassemia/hemoglobin E disease (
20183929
)
Eosinophil counts (
29403010
)
Eosinophil percentage of white cells (
32888494
)
Fetal hemoglobin levels in sickle cell anemia (
25372704
)
Glycated hemoglobin levels (
24647736
28898252
)
HbA2 levels (
23043469
)
Hematocrit (
29403010
19862010
)
Hematological and biochemical traits (
20139978
)
Hematological parameters (
19820697
)
Hematology traits (
23263863
)
Hemoglobin (
29403010
)
Hemoglobin A1c levels (
29403010
)
Hemoglobin levels (
26366553
)
Hodgkin's lymphoma (
24149102
)
Lymphocyte percentage of white cells (
32888494
)
Mean corpuscular hemoglobin (
23263863
29403010
19853236
28453575
20139978
28548082
19862010
28031487
)
Mean corpuscular hemoglobin concentration (
23263863
29403010
20139978
)
Mean corpuscular volume (
23263863
29403010
19853236
28453575
20139978
19862010
28031487
)
Mean platelet volume (
32888494
)
Monocyte percentage of white cells (
32888494
)
Multiple sclerosis (
21833088
)
Myeloproliferative neoplasms (
25849990
)
Neutrophil count (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Obesity-related traits (
23251661
)
Other erythrocyte phenotypes (
19862010
)
Platelet count (
26805783
22139419
24026423
29066854
29403010
19853236
22423221
20139978
28031487
)
Red blood cell count (
29403010
28453575
20139978
28031487
)
Red blood cell traits (
20927387
23935956
)
White blood cell count (
29403010
32888494
20139978
)
White blood cell count (basophil) (
27863252
)
White blood cell types (
21738478
)
Interacting Genes
49 interacting genes:
BTRC
CCND3
CEBPB
CEBPE
CHD3
CNOT9
CREBBP
CSNK2A1
EP300
ERC2
FBXW2
FBXW5
FBXW7
H2AC4
H2BC3
H3-4
H3C1
H4C1
HIPK2
HLF
KAT2A
MAF
MAPK1
MYBBP1A
MYOZ2
NCL
NCOR1
NLK
PAIP1
PAX5
PIAS1
PML
PPM1K
RBX1
RPL4
SIN3A
SKI
SKP2
SMARCA2
SND1
SP100
SUMO1
SUMO2
TRIM28
TTF2
UBE2I
UPF2
ZFHX3
ZMYND11
Entrez ID
4602
HPRD ID
01810
Ensembl ID
ENSG00000118513
Uniprot IDs
P10242
Q708E9
PDB IDs
Enriched GO Terms of Interacting Partners
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