MTHFD1

Description		methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
Image
GO Annotations	Cellular Component	Mitochondrion Cytosol Membrane Extracellular Exosome
	Molecular Function	Formate-tetrahydrofolate Ligase Activity Methenyltetrahydrofolate Cyclohydrolase Activity Methylenetetrahydrofolate Dehydrogenase [NAD(P)+] Activity Methylenetetrahydrofolate Dehydrogenase (NAD+) Activity Methylenetetrahydrofolate Dehydrogenase (NADP+) Activity Protein Binding ATP Binding
	Biological Process	Histidine Biosynthetic Process Neural Tube Closure Purine Nucleotide Biosynthetic Process Methionine Metabolic Process One-carbon Metabolic Process Heart Development Serine Family Amino Acid Metabolic Process Serine Family Amino Acid Biosynthetic Process Methionine Biosynthetic Process 10-formyltetrahydrofolate Biosynthetic Process Tetrahydrofolate Interconversion Folic Acid Metabolic Process Embryonic Neurocranium Morphogenesis Embryonic Viscerocranium Morphogenesis Somite Development
Pathways		Metabolism of folate and pterines
Drugs		Tetrahydrofolic acid NADH LY374571 Nicotinamide adenine dinucleotide phosphate LY249543
Diseases		Spina bifida
GWAS		Atrial fibrillation ( 30061737) Chronotype ( 30696823) Cognitive performance ( 19734545) Longevity ( 30294719) Lymphocyte counts ( 27863252)
Interacting Genes		3 interacting genes: DUX4 ESR1 SUMO2
Entrez ID		4522
HPRD ID		01403
Ensembl ID		ENSG00000100714
Uniprot IDs		A0A384N5Y3 P11586
PDB IDs		1A4I 1DIA 1DIB 1DIG 6ECP 6ECQ 6ECR
Enriched GO Terms of Interacting Partners?
Tagcloud ?