LAMA2

Description		laminin subunit alpha 2
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GO Annotations	Cellular Component	Extracellular Region Basement Membrane Neuromuscular Junction Sarcolemma Synaptic Cleft Dendritic Spine Collagen-containing Extracellular Matrix
	Molecular Function	Signaling Receptor Binding Structural Molecule Activity Extracellular Matrix Structural Constituent
	Biological Process	Cell Adhesion Axon Guidance Muscle Organ Development Animal Organ Morphogenesis Tissue Development Schwann Cell Differentiation Regulation Of Cell Adhesion Extracellular Matrix Organization Regulation Of Cell Migration Positive Regulation Of Synaptic Transmission, Cholinergic Maintenance Of Blood-brain Barrier Regulation Of Embryonic Development
Pathways		Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans MET activates PTK2 signaling EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases		Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Axial length ( 24144296) Body mass index ( 20397748) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Height ( 31562340) High myopia ( 31816047) Hyperopia ( 25233373) Metabolite levels ( 23823483) Myopia ( 27182965 25233373) Night sleep phenotypes ( 27126917) Periodontal disease-related phenotype (Socransky) ( 24347629) Refractive error ( 23396134) Retinal detachment or retinal break ( 31816047) Serum bilirubin levels x Mediterranean diet adherence interaction in metabolic syndrome ( 30621171) Sleep duration (short sleep) ( 30846698) Smoking status (ever vs never smokers) ( 30643258) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Tea consumption ( 31046077)
Interacting Genes		4 interacting genes: DAG1 RPSA SNAPIN TRIM63
Entrez ID		3908
HPRD ID		01125
Ensembl ID		ENSG00000196569
Uniprot IDs		P24043 Q59H37
PDB IDs		4YEP 4YEQ
Enriched GO Terms of Interacting Partners?
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