HES5

Description		hes family bHLH transcription factor 5
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Cellular_component Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Chromatin Binding Transcription Factor Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chondrocyte Differentiation Regulation Of Transcription By RNA Polymerase II Cell Adhesion Notch Signaling Pathway Smoothened Signaling Pathway Brain Development Positive Regulation Of Cell Population Proliferation Anterior/posterior Pattern Specification Oligodendrocyte Development Telencephalon Development Glial Cell Fate Commitment Forebrain Radial Glial Cell Differentiation Neural Tube Development Central Nervous System Myelination Positive Regulation Of BMP Signaling Pathway Regulation Of Myelination Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Camera-type Eye Development Regulation Of Cell Differentiation Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Cell Maturation Positive Regulation Of Smooth Muscle Cell Proliferation Astrocyte Differentiation Negative Regulation Of Astrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Regulation Of Epithelial Cell Proliferation Regulation Of Neurogenesis Cartilage Development Inner Ear Receptor Cell Stereocilium Organization Protein-containing Complex Assembly Comma-shaped Body Morphogenesis S-shaped Body Morphogenesis Specification Of Loop Of Henle Identity Metanephric Nephron Tubule Morphogenesis Establishment Of Epithelial Cell Polarity Neuronal Stem Cell Population Maintenance Negative Regulation Of Stem Cell Differentiation Negative Regulation Of Pro-B Cell Differentiation Negative Regulation Of Forebrain Neuron Differentiation
Pathways		NOTCH1 Intracellular Domain Regulates Transcription NOTCH2 intracellular domain regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription
Drugs
Diseases
GWAS		Body mass index ( 26426971)
Interacting Genes		2 interacting genes: JAK2 STAT3
Entrez ID		388585
HPRD ID		16240
Ensembl ID		ENSG00000197921
Uniprot IDs		Q5TA89
PDB IDs
Enriched GO Terms of Interacting Partners?
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