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ANAPC2
Description
anaphase promoting complex subunit 2
Image
GO Annotations
Cellular Component
Nucleoplasm
Anaphase-promoting Complex
Cytosol
Molecular Function
Protein Binding
Ubiquitin Protein Ligase Binding
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Cell Cycle
Negative Regulation Of Gene Expression
Anaphase-promoting Complex-dependent Catabolic Process
Positive Regulation Of Synaptic Plasticity
Positive Regulation Of Axon Extension
Positive Regulation Of Dendrite Morphogenesis
Cell Division
Protein K11-linked Ubiquitination
Positive Regulation Of Synapse Maturation
Regulation Of Mitotic Cell Cycle Phase Transition
Pathways
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Eosinophil percentage of white cells (
32888494
)
Novel Interacting Genes
1 novel interacting genes:
USP16
Interacting Genes
18 interacting genes:
ANAPC11
ANAPC7
CDC20
CDC26
CDC27
FBXO5
FZR1
MAD2L1
MEOX1
PTTG1
SMAD2
SUMO2
UBC
UBE2C
UBE2D2
UBE2S
UFD1
WDR5
Entrez ID
29882
HPRD ID
07367
Ensembl ID
ENSG00000176248
Uniprot IDs
Q9UJX6
PDB IDs
4UI9
4YII
5A31
5G04
5G05
5KHR
5KHU
5L9T
5L9U
5LCW
6NXK
6OB1
6Q6G
6Q6H
6TLJ
6TM5
Enriched GO Terms of Interacting Partners
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