ANGPTL3

Description		angiopoietin like 3
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Early Endosome Golgi Apparatus Cell Surface Lamellipodium Collagen-containing Extracellular Matrix
	Molecular Function	Enzyme Inhibitor Activity Phospholipase Inhibitor Activity Signaling Receptor Binding Integrin Binding Growth Factor Activity Heparin Binding
	Biological Process	Angiogenesis Glycerol Metabolic Process Fatty Acid Metabolic Process Phospholipid Metabolic Process Cell-matrix Adhesion Signal Transduction Integrin-mediated Signaling Pathway Cholesterol Metabolic Process Phospholipid Catabolic Process Response To Hormone Negative Regulation Of Phospholipase Activity Lipid Storage Positive Regulation Of Cell Migration Cholesterol Homeostasis Positive Regulation Of Angiogenesis Artery Morphogenesis Positive Regulation Of Lipid Catabolic Process Regulation Of Lipoprotein Lipase Activity Negative Regulation Of Lipoprotein Lipase Activity Lipid Homeostasis Acylglycerol Homeostasis Phospholipid Homeostasis Triglyceride Homeostasis
Pathways		Assembly of active LPL and LIPC lipase complexes NR1H2 & NR1H3 regulate gene expression linked to lipogenesis
Drugs
Diseases
GWAS		Blood metabolite levels ( 24816252) Blood protein levels ( 30072576) Cholesterol, total ( 24097068 25961943 20686565 26582766) Crohn's disease ( 28067908) LDL cholesterol ( 24097068 25961943 20686565) LDL cholesterol levels ( 28334899) Lipid metabolism phenotypes ( 22286219 19936222) Metabolite levels ( 22916037) Metabolite levels (lipid measures) ( 27005778) Regular attendance at a gym or sports club ( 29970889) Total cholesterol levels ( 28334899) Total triglycerides levels ( 26690388) Triglyceride levels ( 28334899 29615537) Triglycerides ( 24097068 18193043 18193044 20864672 19060906 20139978 25961943 20686565 26582766)
Interacting Genes		4 interacting genes: ITGA5 ITGAV ITGB3 UBC
Entrez ID		27329
HPRD ID		10381
Ensembl ID		ENSG00000132855
Uniprot IDs		Q9Y5C1
PDB IDs		6EUA
Enriched GO Terms of Interacting Partners?
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